2022 Big 12 Conference Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | TCU | 13 | 27.0 | 178 | 2.08 |
| 2 | West Virginia | 11 | 23.0 | 169 | 2.09 |
| 3 | Kansas State | 12 | 24.0 | 154 | 2.00 |
| 4 | Oklahoma | 11 | 19.0 | 147 | 1.73 |
| 5 | Texas Tech | 11 | 25.0 | 143 | 2.27 |
| 6 | Texas | 11 | 23.0 | 142 | 2.09 |
| 7 | Baylor | 9 | 18.0 | 137 | 2.00 |
| 8 | Oklahoma State | 11 | 19.0 | 119 | 1.73 |
| 9 | Kansas | 11 | 15.0 | 102 | 1.36 |
| 10 | Iowa State | 10 | 14.0 | 97 | 1.40 |