2022 American Athletic Conference Leaders Sacks - Games vs. Ranked Teams Only (AP Poll) through 01/09/2023
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Nelson Paul | SMU | SR | DE | 2 | 3.0 | 25 | 1.50 |
| 1 | Jason Vaughn | S Florida | JR | DE | 1 | 3.0 | 10 | 3.00 |
| 3 | Je'lin Samuels | SMU | FR | DE | 2 | 2.0 | 15 | 1.00 |
| 4 | Colin Ramos | Navy | SO | LB | 1 | 1.5 | 10 | 1.50 |
| 4 | John Marshall | Navy | SR | STR | 1 | 1.5 | 9 | 1.50 |
| 4 | J.D. Lampley | ECU | FR | DL | 1 | 1.5 | 8 | 1.50 |
| 7 | Jason Johnson | UCF | SR | LB | 2 | 1.0 | 12 | 0.50 |
| 7 | Jamykal Neal | Houston | SR | DL | 1 | 1.0 | 11 | 1.00 |
| 7 | Jeremy Lewis | ECU | JR | OLB | 1 | 1.0 | 8 | 1.00 |
| 7 | Jaylon Allen | Memphis | SR | DL | 2 | 1.0 | 8 | 0.50 |
| 7 | Nelson Ceaser | Houston | SO | DL | 1 | 1.0 | 7 | 1.00 |
| 7 | Tre'Mon Morris-Brash | UCF | SR | DE | 2 | 1.0 | 7 | 0.50 |
| 7 | Rayuan Lane III | Navy | SO | FS | 1 | 1.0 | 6 | 1.00 |
| 7 | Eric Phillips | Cincinnati | JR | DL | 1 | 1.0 | 5 | 1.00 |
| 7 | Cormontae Hamilton | Memphis | SO | DL | 2 | 1.0 | 5 | 0.50 |
| 7 | Xavier Smith | ECU | SR | ILB | 1 | 1.0 | 4 | 1.00 |
| 7 | Dwayne Boyles | S Florida | SR | LB | 1 | 1.0 | 3 | 1.00 |
| 7 | Josh Celiscar | UCF | JR | DE | 2 | 1.0 | 2 | 0.50 |
| 7 | Kenney Solomon II | Tulsa | JR | CB | 1 | 1.0 | 1 | 1.00 |
| 20 | Myles Berry | ECU | SR | ILB | 1 | 0.5 | 4 | 0.50 |
| 20 | Elijah Chatman | SMU | SR | DT | 2 | 0.5 | 4 | 0.25 |
| 20 | Nicholas Straw | Navy | SR | RDR | 1 | 0.5 | 3 | 0.50 |
| 20 | Chad Stephens | ECU | SO | DL | 1 | 0.5 | 2 | 0.50 |
| 20 | Shaundre Mims | ECU | SR | DL | 1 | 0.5 | 2 | 0.50 |
| 20 | Clay Cromwell | Navy | JR | DT | 1 | 0.5 | 2 | 0.50 |
| 20 | Joseph Anderson | Tulsa | SR | DL | 1 | 0.5 | 1 | 0.50 |
| 20 | Owen Ostroski | Tulsa | FR | DL | 1 | 0.5 | 1 | 0.50 |
| 20 | Isaac Slade-Matautia | SMU | SR | LB | 2 | 0.5 | 1 | 0.25 |