2022 American Athletic Conference Leaders Total Defense - Games vs. Non-Conference Teams Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Temple | 4 | 520 | 550 | 251 | 1070 | 4.26 | 267.5 |
| 2 | Cincinnati | 5 | 788 | 862 | 380 | 1650 | 4.34 | 330.0 |
| 3 | Navy | 4 | 404 | 642 | 231 | 1046 | 4.53 | 261.5 |
| 4 | Tulane | 5 | 637 | 872 | 324 | 1509 | 4.66 | 301.8 |
| 5 | UCF | 5 | 754 | 852 | 321 | 1606 | 5.00 | 321.2 |
| 6 | Memphis | 5 | 520 | 1255 | 336 | 1775 | 5.28 | 355.0 |
| 7 | SMU | 5 | 931 | 925 | 337 | 1856 | 5.51 | 371.2 |
| 8 | Tulsa | 4 | 785 | 756 | 277 | 1541 | 5.56 | 385.3 |
| 9 | Houston | 5 | 721 | 1373 | 371 | 2094 | 5.64 | 418.8 |
| 10 | East Carolina | 5 | 620 | 1142 | 310 | 1762 | 5.68 | 352.4 |
| 11 | South Florida | 4 | 982 | 882 | 270 | 1864 | 6.90 | 466.0 |