2022 American Athletic Conference Leaders Passing Defense - Games in August/September Only through 01/09/2023
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 5 | 193 | 119 | 61.7 | 1368 | 7.1 | 12 | 5 | 136.54 | 38.6 | 273.6 |
| 1 | Memphis | 4 | 144 | 93 | 64.6 | 1195 | 8.3 | 11 | 5 | 152.56 | 36.0 | 298.8 |
| 3 | Tulane | 5 | 114 | 69 | 60.5 | 618 | 5.4 | 5 | 4 | 113.52 | 22.8 | 123.6 |
| 3 | Cincinnati | 4 | 128 | 65 | 50.8 | 730 | 5.7 | 7 | 4 | 110.49 | 32.0 | 182.5 |
| 3 | South Florida | 4 | 117 | 82 | 70.1 | 882 | 7.5 | 3 | 4 | 135.03 | 29.3 | 220.5 |
| 6 | SMU | 4 | 120 | 69 | 57.5 | 878 | 7.3 | 5 | 3 | 127.71 | 30.0 | 219.5 |
| 6 | East Carolina | 4 | 112 | 65 | 58.0 | 938 | 8.4 | 6 | 3 | 140.71 | 28.0 | 234.5 |
| 8 | Temple | 4 | 90 | 57 | 63.3 | 550 | 6.1 | 4 | 2 | 124.89 | 22.5 | 137.5 |
| 8 | Tulsa | 4 | 102 | 58 | 56.9 | 756 | 7.4 | 7 | 2 | 137.85 | 25.5 | 189.0 |
| 10 | UCF | 4 | 113 | 55 | 48.7 | 679 | 6.0 | 3 | 1 | 106.14 | 28.3 | 169.8 |
| 10 | Navy | 3 | 101 | 66 | 65.3 | 871 | 8.6 | 6 | 1 | 155.42 | 33.7 | 290.3 |