2022 American Athletic Conference Leaders Opponent First Downs - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | East Carolina | 1 | 7 | 11 | 0 | 18 | 18.0 |
| 2 | SMU | 2 | 17 | 19 | 1 | 37 | 18.5 |
| 2 | Temple | 2 | 18 | 16 | 3 | 37 | 18.5 |
| 4 | UCF | 3 | 23 | 34 | 6 | 63 | 21.0 |
| 5 | Tulane | 2 | 14 | 29 | 1 | 44 | 22.0 |
| 6 | South Florida | 2 | 24 | 16 | 5 | 45 | 22.5 |
| 7 | Cincinnati | 3 | 32 | 34 | 8 | 74 | 24.7 |
| 8 | Tulsa | 1 | 15 | 8 | 4 | 27 | 27.0 |
| 9 | Houston | 2 | 27 | 24 | 9 | 60 | 30.0 |
| 10 | Memphis | 1 | 6 | 24 | 4 | 34 | 34.0 |