2016 Atlantic Coast Conference Leaders Total Defense - Games vs. Conference Teams Only through 01/09/2017
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Louisville | 8 | 831 | 1606 | 546 | 2437 | 4.46 | 304.6 |
| 2 | Virginia Tech | 9 | 1321 | 1753 | 624 | 3074 | 4.93 | 341.6 |
| 3 | Clemson | 9 | 1248 | 1865 | 624 | 3113 | 4.99 | 345.9 |
| 4 | Miami (Florida) | 8 | 1255 | 1925 | 602 | 3180 | 5.28 | 397.5 |
| 5 | Florida State | 8 | 1008 | 1947 | 545 | 2955 | 5.42 | 369.4 |
| 5 | Wake Forest | 8 | 1316 | 1757 | 567 | 3073 | 5.42 | 384.1 |
| 7 | North Carolina | 8 | 1802 | 1571 | 617 | 3373 | 5.47 | 421.6 |
| 8 | North Carolina State | 8 | 870 | 2355 | 567 | 3225 | 5.69 | 403.1 |
| 9 | Pittsburgh | 8 | 976 | 2886 | 628 | 3862 | 6.15 | 482.8 |
| 10 | Boston College | 8 | 1241 | 2069 | 537 | 3310 | 6.16 | 413.8 |
| 11 | Virginia | 8 | 1576 | 1855 | 551 | 3431 | 6.23 | 428.9 |
| 12 | Georgia Tech | 8 | 1490 | 2075 | 555 | 3565 | 6.42 | 445.6 |
| 13 | Duke | 8 | 1657 | 2053 | 526 | 3710 | 7.05 | 463.8 |
| 14 | Syracuse | 8 | 2094 | 2243 | 587 | 4337 | 7.39 | 542.1 |