2022 Atlantic Coast Conference Leaders Total Defense - Games vs. Conference Teams Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Florida State | 8 | 1154 | 1270 | 523 | 2424 | 4.63 | 303.0 |
| 2 | Clemson | 9 | 865 | 1978 | 593 | 2843 | 4.79 | 315.9 |
| 3 | Pittsburgh | 8 | 752 | 1798 | 523 | 2550 | 4.88 | 318.8 |
| 4 | Virginia | 7 | 1075 | 1453 | 511 | 2528 | 4.95 | 361.1 |
| 5 | Syracuse | 8 | 1366 | 1601 | 587 | 2967 | 5.05 | 370.9 |
| 6 | North Carolina State | 8 | 906 | 1956 | 526 | 2862 | 5.44 | 357.8 |
| 7 | Georgia Tech | 8 | 1287 | 1855 | 576 | 3142 | 5.45 | 392.8 |
| 8 | Duke | 8 | 882 | 2137 | 543 | 3019 | 5.56 | 377.4 |
| 9 | Boston College | 8 | 1320 | 1806 | 549 | 3126 | 5.69 | 390.8 |
| 10 | Louisville | 8 | 1132 | 1997 | 548 | 3129 | 5.71 | 391.1 |
| 11 | Virginia Tech | 7 | 1032 | 1850 | 504 | 2882 | 5.72 | 411.7 |
| 12 | Miami (Florida) | 8 | 1365 | 1793 | 542 | 3158 | 5.83 | 394.8 |
| 13 | North Carolina | 9 | 1238 | 2478 | 625 | 3716 | 5.95 | 412.9 |
| 14 | Wake Forest | 8 | 1054 | 2516 | 570 | 3570 | 6.26 | 446.3 |