2020 American Athletic Conference Leaders Total Defense - Games in August/September Only through 01/11/2021
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Tulsa | 1 | 141 | 143 | 70 | 284 | 4.06 | 284.0 |
| 2 | Cincinnati | 2 | 322 | 307 | 140 | 629 | 4.49 | 314.5 |
| 3 | South Florida | 2 | 481 | 233 | 138 | 714 | 5.17 | 357.0 |
| 4 | Tulane | 3 | 339 | 766 | 212 | 1105 | 5.21 | 368.3 |
| 5 | SMU | 3 | 452 | 697 | 231 | 1149 | 4.97 | 383.0 |
| 6 | Memphis | 1 | 125 | 299 | 79 | 424 | 5.37 | 424.0 |
| 7 | UCF | 2 | 471 | 459 | 164 | 930 | 5.67 | 465.0 |
| 8 | Navy | 2 | 566 | 387 | 140 | 953 | 6.81 | 476.5 |
| 9 | East Carolina | 1 | 224 | 408 | 87 | 632 | 7.26 | 632.0 |