2018 American Athletic Conference Leaders Total Defense - Games in August/September Only through 01/07/2019
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 5 | 586 | 794 | 317 | 1380 | 4.35 | 276.0 |
| 2 | East Carolina | 4 | 379 | 852 | 252 | 1231 | 4.88 | 307.8 |
| 3 | Memphis | 5 | 922 | 843 | 353 | 1765 | 5.00 | 353.0 |
| 4 | Tulsa | 4 | 725 | 702 | 270 | 1427 | 5.29 | 356.8 |
| 5 | UCF | 4 | 826 | 636 | 294 | 1462 | 4.97 | 365.5 |
| 6 | Temple | 5 | 918 | 935 | 422 | 1853 | 4.39 | 370.6 |
| 7 | Navy | 4 | 639 | 921 | 253 | 1560 | 6.17 | 390.0 |
| 8 | SMU | 5 | 907 | 1118 | 383 | 2025 | 5.29 | 405.0 |
| 9 | South Florida | 4 | 979 | 649 | 311 | 1628 | 5.23 | 407.0 |
| 10 | Tulane | 5 | 781 | 1462 | 375 | 2243 | 5.98 | 448.6 |
| 11 | Houston | 4 | 456 | 1556 | 354 | 2012 | 5.68 | 503.0 |
| 12 | Connecticut | 5 | 1556 | 1759 | 370 | 3315 | 8.96 | 663.0 |