2021 Conference USA Leaders Sacks - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | TJ Johnson | Marshall | SR | DL | 1 | 1.5 | 9 | 1.50 |
| 2 | Tristan Allen | La Tech | JR | DL | 1 | 1.0 | 7 | 1.00 |
| 2 | Josh Carr, Jr. | USM | JR | DL | 1 | 1.0 | 7 | 1.00 |
| 2 | Marcus Haynes | ODU | JR | DE | 1 | 1.0 | 6 | 1.00 |
| 2 | Amorie Morrison | ODU | FR | DE | 1 | 1.0 | 5 | 1.00 |
| 2 | Hayes Maples | USM | SO | LB | 1 | 1.0 | 4 | 1.00 |
| 7 | Kenneth Orji | Rice | JR | RSH | 2 | 1.0 | 9 | 0.50 |
| 7 | Elijah Garcia | Rice | SR | DL | 2 | 1.0 | 6 | 0.50 |
| 7 | Fish McWilliams | UAB | JR | DL | 2 | 1.0 | 5 | 0.50 |
| 7 | Antonio Montero | Rice | JR | LB | 2 | 1.0 | 5 | 0.50 |
| 7 | Owen Porter | Marshall | SO | DL | 1 | 0.5 | 3 | 0.50 |
| 7 | Clarence Hicks | UTSA | SR | OLB | 1 | 0.5 | 3 | 0.50 |
| 7 | Jamal Ligon | UTSA | SO | ILB | 1 | 0.5 | 3 | 0.50 |
| 14 | Josh Pearcy | Rice | FR | OLB | 2 | 0.5 | 4 | 0.25 |
| 14 | Ikenna Enechukwu | Rice | SO | DE | 2 | 0.5 | 4 | 0.25 |
Note: To qualify, player must have played in 75% of his team's games.