2021 Conference USA Leaders Passes Defended - Games in December/January Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Micah Abraham | Marshall | SO | DB | 1 | 0 | 3 | 3 | 3.00 |
| 1 | Quincy Riley | MTSU | FR | CB | 1 | 0 | 3 | 3 | 3.00 |
| 1 | Teldrick Ross | MTSU | SO | S | 1 | 0 | 3 | 3 | 3.00 |
| 4 | Roger Cray | ODU | SR | CB | 1 | 0 | 2 | 2 | 2.00 |
| 4 | Tariq Woolen | UTSA | SR | CB | 1 | 0 | 2 | 2 | 2.00 |
| 4 | Beanie Bishop | Western Ky | SO | DB | 2 | 0 | 2 | 2 | 1.00 |
| 7 | Jahmal Sam | UTSA | SO | S | 1 | 1 | 1 | 2 | 2.00 |
| 7 | Dy'jonn Turner | UAB | SR | S | 1 | 0 | 1 | 1 | 1.00 |
| 7 | Nazeeh Johnson | Marshall | SR | S | 1 | 0 | 1 | 1 | 1.00 |
| 7 | Steven Gilmore | Marshall | JR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 7 | DQ Thomas | MTSU | SR | LB | 1 | 0 | 1 | 1 | 1.00 |
| 7 | Decorian Patterson | MTSU | SO | CB | 1 | 0 | 1 | 1 | 1.00 |
| 7 | Josh Caldwell | UTEP | SR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 7 | Dennis Barnes | UTEP | JR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 7 | Torey Richardson | UTEP | SO | CB | 1 | 0 | 1 | 1 | 1.00 |
| 7 | C.J. Jones | Western Ky | JR | RB | 1 | 0 | 1 | 1 | 1.00 |
| 7 | Kelechi Nwachuku | UTSA | JR | S | 2 | 0 | 1 | 1 | 0.50 |
| 7 | Brandon Matterson | UTSA | SR | DL | 2 | 0 | 1 | 1 | 0.50 |
| 7 | Corey Mayfield Jr. | UTSA | SR | CB | 2 | 0 | 1 | 1 | 0.50 |
| 7 | Dominique Bradshaw | Western Ky | JR | DB | 2 | 0 | 1 | 1 | 0.50 |
| 7 | Darius Shipp | Western Ky | JR | DT | 2 | 0 | 1 | 1 | 0.50 |
| 7 | DeAngelo Malone | Western Ky | SR | DE | 2 | 0 | 1 | 1 | 0.50 |