2021 Conference USA Leaders Opponent Penalties - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Florida Atlantic | 8 | 69 | 623 | 8.6 | 77.9 |
| 2 | Old Dominion | 8 | 69 | 578 | 8.6 | 72.3 |
| 3 | Charlotte | 8 | 67 | 572 | 8.4 | 71.5 |
| 4 | Western Kentucky | 9 | 70 | 625 | 7.8 | 69.4 |
| 5 | Louisiana Tech | 8 | 55 | 545 | 6.9 | 68.1 |
| 6 | North Texas | 8 | 60 | 514 | 7.5 | 64.3 |
| 7 | Rice | 8 | 51 | 507 | 6.4 | 63.4 |
| 8 | Marshall | 8 | 53 | 505 | 6.6 | 63.1 |
| 9 | UTSA | 9 | 70 | 567 | 7.8 | 63.0 |
| 10 | Southern Mississippi | 8 | 54 | 480 | 6.8 | 60.0 |
| 11 | UTEP | 8 | 52 | 468 | 6.5 | 58.5 |
| 12 | UAB | 8 | 50 | 400 | 6.3 | 50.0 |
| 13 | Middle Tennessee | 8 | 49 | 382 | 6.1 | 47.8 |
| 14 | Florida International | 8 | 34 | 303 | 4.3 | 37.9 |