2021 Conference USA Leaders Opponent Penalties - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 4 | 34 | 330 | 8.5 | 82.5 |
| 2 | UTEP | 5 | 41 | 412 | 8.2 | 82.4 |
| 3 | Florida International | 4 | 28 | 285 | 7.0 | 71.3 |
| 4 | Rice | 4 | 28 | 275 | 7.0 | 68.8 |
| 5 | UTSA | 5 | 42 | 339 | 8.4 | 67.8 |
| 6 | Southern Mississippi | 4 | 29 | 265 | 7.3 | 66.3 |
| 7 | North Texas | 5 | 36 | 330 | 7.2 | 66.0 |
| 8 | Old Dominion | 5 | 32 | 325 | 6.4 | 65.0 |
| 9 | Middle Tennessee | 5 | 32 | 284 | 6.4 | 56.8 |
| 10 | Charlotte | 4 | 23 | 216 | 5.8 | 54.0 |
| 11 | UAB | 5 | 26 | 245 | 5.2 | 49.0 |
| 12 | Marshall | 5 | 31 | 244 | 6.2 | 48.8 |
| 13 | Florida Atlantic | 4 | 22 | 192 | 5.5 | 48.0 |
| 14 | Western Kentucky | 5 | 30 | 234 | 6.0 | 46.8 |