2021 Conference USA Leaders Rushing Offense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | North Texas | 8 | 407 | 2054 | 5.05 | 23 | 50.88 | 256.75 |
| 2 | UTSA | 9 | 351 | 1816 | 5.17 | 16 | 39.00 | 201.78 |
| 3 | Rice | 8 | 316 | 1094 | 3.46 | 12 | 39.50 | 136.75 |
| 4 | UAB | 8 | 313 | 1479 | 4.73 | 23 | 39.13 | 184.88 |
| 5 | Old Dominion | 8 | 302 | 1246 | 4.13 | 12 | 37.75 | 155.75 |
| 6 | Florida Atlantic | 8 | 299 | 1146 | 3.83 | 12 | 37.38 | 143.25 |
| 6 | Southern Mississippi | 8 | 299 | 953 | 3.19 | 5 | 37.38 | 119.13 |
| 8 | UTEP | 8 | 286 | 1071 | 3.74 | 12 | 35.75 | 133.88 |
| 9 | Marshall | 8 | 283 | 1243 | 4.39 | 21 | 35.38 | 155.38 |
| 9 | Louisiana Tech | 8 | 283 | 896 | 3.17 | 11 | 35.38 | 112.00 |
| 11 | Middle Tennessee | 8 | 278 | 1097 | 3.95 | 10 | 34.75 | 137.13 |
| 12 | Charlotte | 8 | 277 | 1142 | 4.12 | 8 | 34.63 | 142.75 |
| 13 | Florida International | 8 | 242 | 669 | 2.76 | 5 | 30.25 | 83.63 |
| 14 | Western Kentucky | 9 | 231 | 904 | 3.91 | 8 | 25.67 | 100.44 |