2021 Conference USA Leaders Rushing Offense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | North Texas | 5 | 232 | 989 | 4.26 | 9 | 46.40 | 197.80 |
| 2 | Southern Mississippi | 4 | 166 | 496 | 2.99 | 3 | 41.50 | 124.00 |
| 3 | UTSA | 5 | 206 | 749 | 3.64 | 10 | 41.20 | 149.80 |
| 4 | UAB | 5 | 200 | 863 | 4.32 | 4 | 40.00 | 172.60 |
| 5 | Rice | 4 | 159 | 700 | 4.40 | 7 | 39.75 | 175.00 |
| 6 | UTEP | 5 | 195 | 755 | 3.87 | 6 | 39.00 | 151.00 |
| 7 | Old Dominion | 5 | 192 | 847 | 4.41 | 10 | 38.40 | 169.40 |
| 8 | Charlotte | 4 | 151 | 656 | 4.34 | 5 | 37.75 | 164.00 |
| 9 | Florida Atlantic | 4 | 150 | 675 | 4.50 | 6 | 37.50 | 168.75 |
| 10 | Middle Tennessee | 5 | 179 | 511 | 2.85 | 5 | 35.80 | 102.20 |
| 11 | Marshall | 5 | 166 | 862 | 5.19 | 17 | 33.20 | 172.40 |
| 12 | Louisiana Tech | 4 | 132 | 571 | 4.33 | 5 | 33.00 | 142.75 |
| 13 | Florida International | 4 | 129 | 556 | 4.31 | 6 | 32.25 | 139.00 |
| 14 | Western Kentucky | 5 | 118 | 531 | 4.50 | 5 | 23.60 | 106.20 |