2021 Conference USA Leaders Rushing Offense - Games in October Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Marshall | 4 | 153 | 663 | 4.33 | 13 | 38.25 | 165.75 |
| 2 | Florida Atlantic | 4 | 162 | 673 | 4.15 | 11 | 40.50 | 168.25 |
| 3 | North Texas | 4 | 198 | 900 | 4.55 | 10 | 49.50 | 225.00 |
| 4 | UTSA | 4 | 157 | 770 | 4.90 | 6 | 39.25 | 192.50 |
| 4 | UAB | 4 | 134 | 656 | 4.90 | 6 | 33.50 | 164.00 |
| 4 | UTEP | 4 | 159 | 614 | 3.86 | 6 | 39.75 | 153.50 |
| 7 | Middle Tennessee | 4 | 149 | 544 | 3.65 | 5 | 37.25 | 136.00 |
| 8 | Western Kentucky | 5 | 133 | 564 | 4.24 | 4 | 26.60 | 112.80 |
| 9 | Old Dominion | 4 | 160 | 577 | 3.61 | 3 | 40.00 | 144.25 |
| 9 | Rice | 4 | 164 | 412 | 2.51 | 3 | 41.00 | 103.00 |
| 9 | Florida International | 4 | 117 | 277 | 2.37 | 3 | 29.25 | 69.25 |
| 12 | Charlotte | 4 | 141 | 527 | 3.74 | 2 | 35.25 | 131.75 |
| 13 | Louisiana Tech | 4 | 118 | 352 | 2.98 | 1 | 29.50 | 88.00 |
| 14 | Southern Mississippi | 4 | 135 | 197 | 1.46 | 0 | 33.75 | 49.25 |