2021 Big 12 Conference Leaders Interceptions - All Games through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | JT Woods | Baylor | SR | S | 14 | 6 | 109 | 1 | 0.43 |
| 1 | Al Walcott | Baylor | JR | CB | 12 | 3 | 101 | 1 | 0.25 |
| 1 | Jacobee Bryant | Kansas | FR | CB | 11 | 2 | 31 | 1 | 0.18 |
| 1 | Tre'Vius Hodges-Tomlinson | TCU | JR | CB | 12 | 2 | 29 | 1 | 0.17 |
| 1 | Jake Hummel | Iowa State | SR | LB | 13 | 2 | 24 | 1 | 0.15 |
| 1 | Jason Taylor II | Okla St | JR | S | 14 | 2 | 85 | 1 | 0.14 |
| 1 | Marquis Waters | Texas Tech | SR | DB | 4 | 1 | 72 | 1 | 0.25 |
| 1 | Josh Thompson | Texas | SR | DB | 9 | 1 | 27 | 1 | 0.11 |
| 1 | Gavin Potter | Kansas | JR | LB | 12 | 1 | 28 | 1 | 0.08 |
| 1 | Riko Jeffers | Texas Tech | SR | LB | 13 | 1 | 13 | 1 | 0.08 |