2021 Big 12 Conference Leaders Interceptions - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Al Walcott | Baylor | JR | CB | 8 | 3 | 101 | 1 | 0.38 |
| 1 | Tre'Vius Hodges-Tomlinson | TCU | JR | CB | 7 | 1 | 29 | 1 | 0.14 |
| 1 | Josh Thompson | Texas | SR | DB | 7 | 1 | 27 | 1 | 0.14 |
| 1 | Riko Jeffers | Texas Tech | SR | LB | 7 | 1 | 13 | 1 | 0.14 |