2021 Big 12 Conference Leaders Tackles For Loss - Games at Home Only through 01/10/2022
| Name | Team | Yr | Pos | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Felix Anudike-Uzomah | Kansas St | SO | DE | 7 | 10.0 | 41 | 1.43 |
| 1 | Malcolm Rodriguez | Okla St | SR | LB | 7 | 10.0 | 31 | 1.43 |
| 3 | Daniel Green | Kansas St | JR | LB | 7 | 9.0 | 44 | 1.29 |
| 4 | Will McDonald IV | Iowa State | JR | DE | 6 | 8.0 | 50 | 1.33 |
| 4 | Dylan Horton | TCU | SR | DE | 7 | 8.0 | 42 | 1.14 |
| 4 | Jalen Pitre | Baylor | SR | S | 7 | 8.0 | 35 | 1.14 |
| 4 | Dante Stills | WVU | SR | DL | 6 | 8.0 | 27 | 1.33 |
| 8 | Tyler Lacy | Okla St | JR | DE | 7 | 7.0 | 28 | 1.00 |
| 9 | Eyioma Uwazurike | Iowa State | SR | DE | 6 | 6.5 | 50 | 1.08 |
| 9 | Terrel Bernard | Baylor | SR | LB | 7 | 6.5 | 35 | 0.93 |
| 9 | Tyree Wilson | Texas Tech | JR | DL | 6 | 6.5 | 29 | 1.08 |
| 9 | Collin Oliver | Okla St | FR | DE | 7 | 6.5 | 29 | 0.93 |
| 9 | Nik Bonitto | Oklahoma | JR | OLB | 7 | 6.5 | 29 | 0.93 |
| 14 | Isaiah Thomas | Oklahoma | SR | DL | 7 | 6.0 | 41 | 0.86 |
| 14 | Taijh Alston | WVU | JR | DL | 6 | 6.0 | 33 | 1.00 |
| 16 | Dillon Doyle | Baylor | JR | LB | 7 | 5.5 | 17 | 0.79 |
| 17 | Perrion Winfrey | Oklahoma | SR | DL | 7 | 5.0 | 26 | 0.71 |
| 17 | TJ Franklin | Baylor | JR | DL | 7 | 5.0 | 22 | 0.71 |
| 17 | Tony Bradford Jr. | Texas Tech | JR | DL | 5 | 5.0 | 13 | 1.00 |
| 17 | Mike Rose | Iowa State | SR | LB | 6 | 5.0 | 10 | 0.83 |
| 21 | Nate Matlack | Kansas St | FR | DE | 7 | 4.5 | 34 | 0.64 |
| 21 | Devin Harper | Okla St | SR | LB | 7 | 4.5 | 27 | 0.64 |
| 21 | DaShaun White | Oklahoma | SR | LB | 7 | 4.5 | 10 | 0.64 |
| 24 | Jalen Redmond | Oklahoma | SO | DL | 5 | 4.0 | 20 | 0.80 |
| 24 | Jaylon Hutchings | Texas Tech | JR | DL | 6 | 4.0 | 17 | 0.67 |
| 24 | Ray Thornton | Texas | SR | EDG | 6 | 4.0 | 16 | 0.67 |
| 24 | Ovie Oghoufo | Texas | JR | EDG | 6 | 4.0 | 11 | 0.67 |
| 24 | Isaiah Coe | Oklahoma | JR | DL | 7 | 4.0 | 8 | 0.57 |
| 24 | Jaylan Ford | Texas | SO | LB | 6 | 4.0 | 4 | 0.67 |
| 30 | Akheem Mesidor | WVU | SO | DL | 6 | 3.5 | 32 | 0.58 |
| 30 | Matt Jones | Baylor | SO | LB | 7 | 3.5 | 25 | 0.50 |
| 30 | Caleb Sampson | Kansas | SR | DL | 6 | 3.5 | 16 | 0.58 |
| 30 | Reggie Stubblefield | Kansas St | SR | DB | 7 | 3.5 | 16 | 0.50 |
| 30 | Jake Hummel | Iowa State | SR | LB | 6 | 3.5 | 14 | 0.58 |
| 30 | Eli Huggins | Kansas St | SR | DT | 7 | 3.5 | 14 | 0.50 |
| 30 | Israel Antwine | Okla St | SR | DT | 6 | 3.5 | 13 | 0.58 |
| 30 | Gavin Potter | Kansas | JR | LB | 6 | 3.5 | 10 | 0.58 |
| 30 | Luke Brockermeyer | Texas | JR | LB | 5 | 3.5 | 7 | 0.70 |
| 30 | Patrick Fields | Oklahoma | SR | S | 7 | 3.5 | 7 | 0.50 |
| 30 | Cody Fletcher | Kansas St | SR | LB | 7 | 3.5 | 6 | 0.50 |
| 41 | Siaki Ika | Baylor | SO | DT | 6 | 3.0 | 21 | 0.50 |
| 41 | Bryson Jackson | Baylor | SR | OLB | 7 | 3.0 | 20 | 0.43 |
| 41 | Jared Bartlett | WVU | SO | BAN | 6 | 3.0 | 19 | 0.50 |
| 41 | Kyron Johnson | Kansas | SR | DE | 6 | 3.0 | 18 | 0.50 |
| 41 | Rich Miller | Kansas | JR | LB | 6 | 3.0 | 16 | 0.50 |
| 41 | Ashton Logan | Baylor | SR | OLB | 7 | 3.0 | 15 | 0.43 |
| 41 | Timmy Horne | Kansas St | SR | DT | 7 | 3.0 | 13 | 0.43 |
| 41 | Alfred Collins | Texas | SO | DL | 6 | 3.0 | 11 | 0.50 |
| 41 | Krishon Merriweather | Texas Tech | SR | LB | 6 | 3.0 | 9 | 0.50 |
| 50 | Josh Chandler-Semedo | WVU | SR | LB | 6 | 2.5 | 14 | 0.42 |