2021 Big 12 Conference Leaders Tackles For Loss - Games at Home Only through 01/10/2022
| Name | Team | Yr | Pos | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Will McDonald IV | Iowa State | JR | DE | 6 | 8.0 | 50 | 1.33 |
| 1 | Eyioma Uwazurike | Iowa State | SR | DE | 6 | 6.5 | 50 | 1.08 |
| 3 | Daniel Green | Kansas St | JR | LB | 7 | 9.0 | 44 | 1.29 |
| 4 | Dylan Horton | TCU | SR | DE | 7 | 8.0 | 42 | 1.14 |
| 5 | Felix Anudike-Uzomah | Kansas St | SO | DE | 7 | 10.0 | 41 | 1.43 |
| 5 | Isaiah Thomas | Oklahoma | SR | DL | 7 | 6.0 | 41 | 0.86 |
| 7 | Jalen Pitre | Baylor | SR | S | 7 | 8.0 | 35 | 1.14 |
| 7 | Terrel Bernard | Baylor | SR | LB | 7 | 6.5 | 35 | 0.93 |
| 9 | Nate Matlack | Kansas St | FR | DE | 7 | 4.5 | 34 | 0.64 |
| 10 | Taijh Alston | WVU | JR | DL | 6 | 6.0 | 33 | 1.00 |
| 11 | Akheem Mesidor | WVU | SO | DL | 6 | 3.5 | 32 | 0.58 |
| 12 | Malcolm Rodriguez | Okla St | SR | LB | 7 | 10.0 | 31 | 1.43 |
| 13 | Tyree Wilson | Texas Tech | JR | DL | 6 | 6.5 | 29 | 1.08 |
| 13 | Collin Oliver | Okla St | FR | DE | 7 | 6.5 | 29 | 0.93 |
| 13 | Nik Bonitto | Oklahoma | JR | OLB | 7 | 6.5 | 29 | 0.93 |
| 16 | Tyler Lacy | Okla St | JR | DE | 7 | 7.0 | 28 | 1.00 |
| 17 | Dante Stills | WVU | SR | DL | 6 | 8.0 | 27 | 1.33 |
| 17 | Devin Harper | Okla St | SR | LB | 7 | 4.5 | 27 | 0.64 |
| 19 | Perrion Winfrey | Oklahoma | SR | DL | 7 | 5.0 | 26 | 0.71 |
| 20 | Matt Jones | Baylor | SO | LB | 7 | 3.5 | 25 | 0.50 |
| 21 | TJ Franklin | Baylor | JR | DL | 7 | 5.0 | 22 | 0.71 |
| 21 | Malcolm Lee | Kansas | SR | DL | 6 | 2.0 | 22 | 0.33 |
| 23 | Siaki Ika | Baylor | SO | DT | 6 | 3.0 | 21 | 0.50 |
| 24 | Jalen Redmond | Oklahoma | SO | DL | 5 | 4.0 | 20 | 0.80 |
| 24 | Bryson Jackson | Baylor | SR | OLB | 7 | 3.0 | 20 | 0.43 |
| 26 | Jared Bartlett | WVU | SO | BAN | 6 | 3.0 | 19 | 0.50 |
| 26 | Key Lawrence | Oklahoma | SO | DB | 7 | 1.5 | 19 | 0.21 |
| 28 | Kyron Johnson | Kansas | SR | DE | 6 | 3.0 | 18 | 0.50 |
| 28 | Reggie Grimes | Oklahoma | SO | DE | 7 | 2.0 | 18 | 0.29 |
| 30 | Dillon Doyle | Baylor | JR | LB | 7 | 5.5 | 17 | 0.79 |
| 30 | Jaylon Hutchings | Texas Tech | JR | DL | 6 | 4.0 | 17 | 0.67 |
| 32 | Ray Thornton | Texas | SR | EDG | 6 | 4.0 | 16 | 0.67 |
| 32 | Caleb Sampson | Kansas | SR | DL | 6 | 3.5 | 16 | 0.58 |
| 32 | Reggie Stubblefield | Kansas St | SR | DB | 7 | 3.5 | 16 | 0.50 |
| 32 | Rich Miller | Kansas | JR | LB | 6 | 3.0 | 16 | 0.50 |
| 36 | Ashton Logan | Baylor | SR | OLB | 7 | 3.0 | 15 | 0.43 |
| 36 | Jacob Morgenstern | Texas Tech | SR | LB | 4 | 1.0 | 15 | 0.25 |
| 38 | Jake Hummel | Iowa State | SR | LB | 6 | 3.5 | 14 | 0.58 |
| 38 | Eli Huggins | Kansas St | SR | DT | 7 | 3.5 | 14 | 0.50 |
| 38 | Josh Chandler-Semedo | WVU | SR | LB | 6 | 2.5 | 14 | 0.42 |
| 41 | Tony Bradford Jr. | Texas Tech | JR | DL | 5 | 5.0 | 13 | 1.00 |
| 41 | Israel Antwine | Okla St | SR | DT | 6 | 3.5 | 13 | 0.58 |
| 41 | Timmy Horne | Kansas St | SR | DT | 7 | 3.0 | 13 | 0.43 |
| 41 | Dee Winters | TCU | JR | LB | 7 | 2.5 | 13 | 0.36 |
| 45 | Ovie Oghoufo | Texas | JR | EDG | 6 | 4.0 | 11 | 0.67 |
| 45 | Alfred Collins | Texas | SO | DL | 6 | 3.0 | 11 | 0.50 |
| 45 | Jacoby Jones | Texas | SR | EDG | 4 | 2.5 | 11 | 0.63 |
| 45 | Nook Bradford | TCU | JR | S | 6 | 2.5 | 11 | 0.42 |
| 45 | Alonzo Addae | WVU | SR | S | 6 | 2.5 | 11 | 0.42 |
| 45 | Mason Cobb | Okla St | SO | LB | 7 | 2.0 | 11 | 0.29 |