2021 Big 12 Conference Leaders Rushing - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Roschon Johnson | Texas | JR | RB | 3 | 12 | 142 | 11.83 | 1 | 4.00 | 47.33 |
| 2 | Trestan Ebner | Baylor | SR | RB | 4 | 47 | 376 | 8.00 | 0 | 11.75 | 94.00 |
| 3 | Caleb Williams | Oklahoma | FR | QB | 3 | 12 | 95 | 7.92 | 1 | 4.00 | 31.67 |
| 4 | Zach Evans | TCU | SO | RB | 3 | 42 | 330 | 7.86 | 2 | 14.00 | 110.00 |
| 5 | Tahj Brooks | Texas Tech | SO | RB | 4 | 51 | 391 | 7.67 | 5 | 12.75 | 97.75 |
| 6 | Kennedy Brooks | Oklahoma | JR | RB | 4 | 48 | 352 | 7.33 | 6 | 12.00 | 88.00 |
| 7 | Abram Smith | Baylor | SR | RB | 4 | 83 | 604 | 7.28 | 7 | 20.75 | 151.00 |
| 8 | Keilan Robinson | Texas | JR | RB | 3 | 19 | 133 | 7.00 | 1 | 6.33 | 44.33 |
| 8 | Garrett Greene | WVU | FR | QB | 3 | 18 | 126 | 7.00 | 2 | 6.00 | 42.00 |
| 10 | Eric Gray | Oklahoma | JR | RB | 4 | 41 | 267 | 6.51 | 0 | 10.25 | 66.75 |
| 11 | Xavier White | Texas Tech | JR | RB | 4 | 22 | 138 | 6.27 | 1 | 5.50 | 34.50 |
| 12 | Deuce Vaughn | Kansas St | SO | RB | 4 | 83 | 517 | 6.23 | 8 | 20.75 | 129.25 |
| 13 | Kendre Miller | TCU | SO | RB | 3 | 17 | 99 | 5.82 | 2 | 5.67 | 33.00 |
| 14 | Bijan Robinson | Texas | SO | RB | 3 | 52 | 299 | 5.75 | 5 | 17.33 | 99.67 |
| 15 | Joe Ervin | Kansas St | SO | RB | 3 | 24 | 131 | 5.46 | 1 | 8.00 | 43.67 |
| 16 | Spencer Sanders | Okla St | JR | QB | 3 | 42 | 227 | 5.40 | 1 | 14.00 | 75.67 |
| 17 | Leddie Brown | WVU | SR | RB | 3 | 51 | 265 | 5.20 | 5 | 17.00 | 88.33 |
| 18 | Justin Johnson Jr. | WVU | FR | RB | 3 | 15 | 77 | 5.13 | 0 | 5.00 | 25.67 |
| 19 | Devin Neal | Kansas | FR | RB | 3 | 29 | 148 | 5.10 | 2 | 9.67 | 49.33 |
| 20 | Jaylen Warren | Okla St | SR | RB | 4 | 71 | 346 | 4.87 | 4 | 17.75 | 86.50 |
| 21 | Jason Bean | Kansas | JR | QB | 3 | 43 | 208 | 4.84 | 2 | 14.33 | 69.33 |
| 22 | Torry Locklin | Kansas | SO | WR | 3 | 15 | 66 | 4.40 | 1 | 5.00 | 22.00 |
| 23 | Brock Purdy | Iowa State | SR | QB | 4 | 26 | 106 | 4.08 | 0 | 6.50 | 26.50 |
| 24 | Breece Hall | Iowa State | JR | RB | 3 | 60 | 238 | 3.97 | 4 | 20.00 | 79.33 |
| 25 | Spencer Rattler | Oklahoma | SO | QB | 3 | 18 | 71 | 3.94 | 2 | 6.00 | 23.67 |
| 26 | Tony Mathis Jr. | WVU | SO | RB | 3 | 22 | 81 | 3.68 | 0 | 7.33 | 27.00 |
| 27 | Gerry Bohanon | Baylor | JR | QB | 4 | 18 | 66 | 3.67 | 2 | 4.50 | 16.50 |
| 28 | Max Duggan | TCU | JR | QB | 3 | 31 | 110 | 3.55 | 2 | 10.33 | 36.67 |
| 29 | Jirehl Brock | Iowa State | SO | RB | 4 | 20 | 69 | 3.45 | 0 | 5.00 | 17.25 |
| 30 | Will Howard | Kansas St | SO | QB | 3 | 20 | 65 | 3.25 | 3 | 6.67 | 21.67 |
| 31 | Skylar Thompson | Kansas St | SR | QB | 3 | 15 | 43 | 2.87 | 2 | 5.00 | 14.33 |
| 32 | LD Brown | Okla St | SR | RB | 4 | 31 | 85 | 2.74 | 1 | 7.75 | 21.25 |
| 33 | Hudson Card | Texas | FR | QB | 3 | 15 | 14 | 0.93 | 1 | 5.00 | 4.67 |
| 34 | Tyler Shough | Texas Tech | JR | QB | 3 | 15 | 8 | 0.53 | 1 | 5.00 | 2.67 |
| 35 | Jarret Doege | WVU | SR | QB | 4 | 20 | -48 | -2.40 | 1 | 5.00 | -12.00 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 4.0 rushing attempts per game played.