2021 Big 12 Conference Leaders Tackles For Loss - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Jalen Pitre | Baylor | SR | S | 4 | 7.5 | 33 | 1.88 |
| 2 | Mike Rose | Iowa State | SR | LB | 3 | 4.5 | 13 | 1.50 |
| 3 | Brock Martin | Okla St | SR | DE | 4 | 5.5 | 30 | 1.38 |
| 4 | Tyree Wilson | Texas Tech | JR | DL | 4 | 5.0 | 32 | 1.25 |
| 4 | Jackie Matthews | WVU | JR | CB | 4 | 5.0 | 18 | 1.25 |
| 6 | Nik Bonitto | Oklahoma | JR | OLB | 3 | 3.5 | 11 | 1.17 |
| 7 | Terrel Bernard | Baylor | SR | LB | 4 | 4.5 | 26 | 1.13 |
| 8 | Dante Stills | WVU | SR | DL | 4 | 4.0 | 26 | 1.00 |
| 8 | Zach Petersen | Iowa State | SR | DE | 4 | 4.0 | 11 | 1.00 |
| 8 | Colin Schooler | Texas Tech | SR | LB | 4 | 4.0 | 9 | 1.00 |
| 8 | Perrion Winfrey | Oklahoma | SR | DL | 3 | 3.0 | 12 | 1.00 |
| 8 | Ovie Oghoufo | Texas | JR | EDG | 3 | 3.0 | 9 | 1.00 |
| 8 | Luke Brockermeyer | Texas | JR | LB | 3 | 3.0 | 7 | 1.00 |
| 14 | Tony Bradford Jr. | Texas Tech | JR | DL | 4 | 3.5 | 21 | 0.88 |
| 14 | Taijh Alston | WVU | JR | DL | 4 | 3.5 | 21 | 0.88 |
| 14 | Jared Bartlett | WVU | SO | BAN | 4 | 3.5 | 20 | 0.88 |
| 14 | Devin Harper | Okla St | SR | LB | 4 | 3.5 | 19 | 0.88 |
| 14 | Jalen Redmond | Oklahoma | SO | DL | 4 | 3.5 | 18 | 0.88 |
| 14 | Dillon Doyle | Baylor | JR | LB | 4 | 3.5 | 15 | 0.88 |
| 14 | Jahron McPherson | Kansas St | SR | DB | 4 | 3.5 | 12 | 0.88 |
| 14 | Krishon Merriweather | Texas Tech | SR | LB | 4 | 3.5 | 11 | 0.88 |
| 22 | Isaiah Thomas | Oklahoma | SR | DL | 3 | 2.5 | 21 | 0.83 |
| 22 | Dee Winters | TCU | JR | LB | 3 | 2.5 | 13 | 0.83 |
| 22 | Kyron Johnson | Kansas | SR | DE | 3 | 2.5 | 8 | 0.83 |
| 22 | Caleb Taylor | Kansas | FR | DL | 3 | 2.5 | 6 | 0.83 |
| 26 | Bryson Jackson | Baylor | SR | OLB | 4 | 3.0 | 24 | 0.75 |
| 26 | Jaylon Hutchings | Texas Tech | JR | DL | 4 | 3.0 | 20 | 0.75 |
| 26 | Will McDonald IV | Iowa State | JR | DE | 4 | 3.0 | 18 | 0.75 |
| 26 | Eyioma Uwazurike | Iowa State | SR | DE | 4 | 3.0 | 16 | 0.75 |
| 26 | Felix Anudike-Uzomah | Kansas St | SO | DE | 4 | 3.0 | 14 | 0.75 |
| 26 | Daniel Green | Kansas St | JR | LB | 4 | 3.0 | 11 | 0.75 |
| 26 | Alonzo Addae | WVU | SR | S | 4 | 3.0 | 11 | 0.75 |
| 26 | Gerry Vaughn | Iowa State | JR | LB | 4 | 3.0 | 10 | 0.75 |
| 26 | Isaiah Coe | Oklahoma | JR | DL | 4 | 3.0 | 5 | 0.75 |
| 35 | Khalid Duke | Kansas St | JR | DE | 3 | 2.0 | 17 | 0.67 |
| 35 | Ochaun Mathis | TCU | JR | DE | 3 | 2.0 | 8 | 0.67 |
| 35 | Tre'Vius Hodges-Tomlinson | TCU | JR | CB | 3 | 2.0 | 6 | 0.67 |
| 35 | Spencer Trussell | Kansas St | JR | DE | 3 | 2.0 | 4 | 0.67 |
| 35 | Dylan Horton | TCU | SR | DE | 3 | 2.0 | 2 | 0.67 |
| 40 | Ashton Logan | Baylor | SR | OLB | 4 | 2.5 | 14 | 0.63 |
| 40 | Jake Hummel | Iowa State | SR | LB | 4 | 2.5 | 13 | 0.63 |
| 40 | Akheem Mesidor | WVU | SO | DL | 4 | 2.5 | 13 | 0.63 |
| 40 | Brayden Utley | Baylor | JR | DL | 4 | 2.5 | 11 | 0.63 |
| 40 | TJ Franklin | Baylor | JR | DL | 4 | 2.5 | 11 | 0.63 |
| 40 | Cody Fletcher | Kansas St | SR | LB | 4 | 2.5 | 10 | 0.63 |
| 40 | Tyler Lacy | Okla St | JR | DE | 4 | 2.5 | 7 | 0.63 |
| 47 | Reggie Grimes | Oklahoma | SO | DE | 4 | 2.0 | 21 | 0.50 |
| 47 | Matt Jones | Baylor | SO | LB | 4 | 2.0 | 11 | 0.50 |
| 47 | Collin Oliver | Okla St | FR | DE | 4 | 2.0 | 7 | 0.50 |
| 47 | Marcus Stripling | Oklahoma | JR | DE | 4 | 2.0 | 7 | 0.50 |
Note: To qualify, player must have played in 75% of his team's games.