2021 Big 12 Conference Leaders Tackles For Loss - Games in August/September Only through 01/10/2022
| Name | Team | Yr | Pos | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Mike Rose | Iowa State | SR | LB | 4 | 6.0 | 16 | 1.50 |
| 2 | Jalen Pitre | Baylor | SR | S | 4 | 5.5 | 13 | 1.38 |
| 3 | Will McDonald IV | Iowa State | JR | DE | 4 | 5.0 | 33 | 1.25 |
| 3 | Dillon Doyle | Baylor | JR | LB | 4 | 5.0 | 7 | 1.25 |
| 5 | Taijh Alston | WVU | JR | DL | 4 | 4.5 | 26 | 1.13 |
| 5 | Brock Martin | Okla St | SR | DE | 4 | 4.5 | 22 | 1.13 |
| 5 | Eyioma Uwazurike | Iowa State | SR | DE | 4 | 4.5 | 20 | 1.13 |
| 5 | Jahron McPherson | Kansas St | SR | DB | 4 | 4.5 | 13 | 1.13 |
| 9 | Perrion Winfrey | Oklahoma | SR | DL | 4 | 4.0 | 20 | 1.00 |
| 9 | Tyree Wilson | Texas Tech | JR | DL | 4 | 4.0 | 20 | 1.00 |
| 9 | Jared Bartlett | WVU | SO | BAN | 4 | 4.0 | 20 | 1.00 |
| 9 | Felix Anudike-Uzomah | Kansas St | SO | DE | 4 | 4.0 | 16 | 1.00 |
| 13 | Tyler Lacy | Okla St | JR | DE | 4 | 3.5 | 19 | 0.88 |
| 13 | Ashton Logan | Baylor | SR | OLB | 4 | 3.5 | 15 | 0.88 |
| 13 | Nik Bonitto | Oklahoma | JR | OLB | 4 | 3.5 | 11 | 0.88 |
| 16 | Jalen Redmond | Oklahoma | SO | DL | 3 | 2.5 | 13 | 0.83 |
| 16 | Dee Winters | TCU | JR | LB | 3 | 2.5 | 13 | 0.83 |
| 18 | Jaylon Hutchings | Texas Tech | JR | DL | 4 | 3.0 | 20 | 0.75 |
| 18 | Dante Stills | WVU | SR | DL | 4 | 3.0 | 19 | 0.75 |
| 18 | Matt Jones | Baylor | SO | LB | 4 | 3.0 | 14 | 0.75 |
| 18 | Jake Hummel | Iowa State | SR | LB | 4 | 3.0 | 14 | 0.75 |
| 18 | Alonzo Addae | WVU | SR | S | 4 | 3.0 | 11 | 0.75 |
| 18 | Ovie Oghoufo | Texas | JR | EDG | 4 | 3.0 | 9 | 0.75 |
| 18 | Sean Mahone | WVU | SR | S | 4 | 3.0 | 9 | 0.75 |
| 18 | Luke Brockermeyer | Texas | JR | LB | 4 | 3.0 | 7 | 0.75 |
| 18 | Jackie Matthews | WVU | JR | CB | 4 | 3.0 | 7 | 0.75 |
| 18 | Isaiah Coe | Oklahoma | JR | DL | 4 | 3.0 | 5 | 0.75 |
| 18 | Malcolm Rodriguez | Okla St | SR | LB | 4 | 3.0 | 3 | 0.75 |
| 29 | Khalid Duke | Kansas St | JR | DE | 3 | 2.0 | 17 | 0.67 |
| 29 | Israel Antwine | Okla St | SR | DT | 3 | 2.0 | 8 | 0.67 |
| 29 | Ochaun Mathis | TCU | JR | DE | 3 | 2.0 | 8 | 0.67 |
| 29 | Tre'Vius Hodges-Tomlinson | TCU | JR | CB | 3 | 2.0 | 6 | 0.67 |
| 29 | Dylan Horton | TCU | SR | DE | 3 | 2.0 | 2 | 0.67 |
| 34 | Isaiah Thomas | Oklahoma | SR | DL | 4 | 2.5 | 21 | 0.63 |
| 34 | Devin Harper | Okla St | SR | LB | 4 | 2.5 | 16 | 0.63 |
| 34 | Akheem Mesidor | WVU | SO | DL | 4 | 2.5 | 13 | 0.63 |
| 34 | Tony Bradford Jr. | Texas Tech | JR | DL | 4 | 2.5 | 11 | 0.63 |
| 34 | Zach Petersen | Iowa State | SR | DE | 4 | 2.5 | 10 | 0.63 |
| 34 | Cody Fletcher | Kansas St | SR | LB | 4 | 2.5 | 10 | 0.63 |
| 34 | Gerry Vaughn | Iowa State | JR | LB | 4 | 2.5 | 9 | 0.63 |
| 34 | Kyron Johnson | Kansas | SR | DE | 4 | 2.5 | 8 | 0.63 |
| 34 | Krishon Merriweather | Texas Tech | SR | LB | 4 | 2.5 | 7 | 0.63 |
| 34 | Caleb Taylor | Kansas | FR | DL | 4 | 2.5 | 6 | 0.63 |
| 34 | TJ Franklin | Baylor | JR | DL | 4 | 2.5 | 4 | 0.63 |
| 34 | Kolby Harvell-Peel | Okla St | SR | S | 4 | 2.5 | 3 | 0.63 |
| 46 | Eli Huggins | Kansas St | SR | DT | 4 | 2.0 | 9 | 0.50 |
| 46 | Alfred Collins | Texas | SO | DL | 4 | 2.0 | 9 | 0.50 |
| 46 | Colin Schooler | Texas Tech | SR | LB | 4 | 2.0 | 7 | 0.50 |
| 46 | Daniel Green | Kansas St | JR | LB | 4 | 2.0 | 6 | 0.50 |
| 46 | Kori Roberson | Oklahoma | SO | DL | 4 | 2.0 | 6 | 0.50 |
Note: To qualify, player must have played in 75% of his team's games.