2021 Big 12 Conference Leaders Sacks - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Eyioma Uwazurike | Iowa State | SR | DE | 5 | 4.5 | 41 | 0.90 |
| 2 | Jared Bartlett | WVU | SO | BAN | 4 | 3.5 | 25 | 0.88 |
| 3 | Nik Bonitto | Oklahoma | JR | OLB | 6 | 5.0 | 26 | 0.83 |
| 3 | Felix Anudike-Uzomah | Kansas St | SO | DE | 6 | 5.0 | 24 | 0.83 |
| 5 | Dylan Horton | TCU | SR | DE | 4 | 3.0 | 35 | 0.75 |
| 5 | Kyron Johnson | Kansas | SR | DE | 4 | 3.0 | 15 | 0.75 |
| 5 | Collin Oliver | Okla St | FR | DE | 4 | 3.0 | 15 | 0.75 |
| 8 | Will McDonald IV | Iowa State | JR | DE | 5 | 3.5 | 22 | 0.70 |
| 9 | Siaki Ika | Baylor | SO | DT | 5 | 3.0 | 21 | 0.60 |
| 10 | Perrion Winfrey | Oklahoma | SR | DL | 6 | 3.0 | 18 | 0.50 |
| 10 | Eli Huggins | Kansas St | SR | DT | 6 | 3.0 | 16 | 0.50 |
| 10 | Tyler Lacy | Okla St | JR | DE | 4 | 2.0 | 17 | 0.50 |
| 10 | Akheem Mesidor | WVU | SO | DL | 4 | 2.0 | 14 | 0.50 |
| 10 | Brock Martin | Okla St | SR | DE | 4 | 2.0 | 13 | 0.50 |
| 10 | Devin Harper | Okla St | SR | LB | 4 | 2.0 | 13 | 0.50 |
| 16 | Isaiah Thomas | Oklahoma | SR | DL | 6 | 2.5 | 13 | 0.42 |
| 17 | Terrel Bernard | Baylor | SR | LB | 5 | 2.0 | 18 | 0.40 |
| 18 | Taijh Alston | WVU | JR | DL | 4 | 1.5 | 14 | 0.38 |
| 18 | Kamryn Farrar | Okla St | SO | LB | 4 | 1.5 | 4 | 0.38 |
| 18 | Israel Antwine | Okla St | SR | DT | 4 | 1.5 | 4 | 0.38 |
| 21 | Ben Davis | Texas | SR | EDG | 3 | 1.0 | 16 | 0.33 |
| 21 | Zion DeBose | Kansas | SR | DE | 3 | 1.0 | 7 | 0.33 |
| 21 | Corey Bethley | TCU | SR | DT | 3 | 1.0 | 7 | 0.33 |
| 21 | Tyren Irby | Okla St | SR | DE | 3 | 1.0 | 3 | 0.33 |
| 21 | Jereme Robinson | Kansas | SO | DL | 3 | 1.0 | 2 | 0.33 |
| 26 | Jason Taylor II | Okla St | JR | S | 4 | 1.0 | 26 | 0.25 |
| 26 | Anthony Cook | Texas | SR | DB | 4 | 1.0 | 16 | 0.25 |
| 26 | Rich Miller | Kansas | JR | LB | 4 | 1.0 | 14 | 0.25 |
| 26 | Victor Obi | Baylor | JR | OLB | 4 | 1.0 | 10 | 0.25 |
| 26 | Dee Winters | TCU | JR | LB | 4 | 1.0 | 9 | 0.25 |
| 26 | Nate Betts | Kansas | SR | LB | 4 | 1.0 | 7 | 0.25 |
| 26 | Jayden Jernigan | Okla St | SO | DT | 4 | 1.0 | 7 | 0.25 |
| 26 | Kody Walterscheid | Okla St | SO | DE | 4 | 1.0 | 7 | 0.25 |
| 26 | Dante Stills | WVU | SR | DL | 4 | 1.0 | 7 | 0.25 |
| 26 | Kolby Harvell-Peel | Okla St | SR | S | 4 | 1.0 | 6 | 0.25 |
| 26 | Alonzo Addae | WVU | SR | S | 4 | 1.0 | 6 | 0.25 |
| 26 | Byron Murphy II | Texas | FR | DL | 4 | 1.0 | 5 | 0.25 |
| 26 | Garmon Randolph | Baylor | SO | OLB | 4 | 1.0 | 4 | 0.25 |
| 26 | Malcolm Rodriguez | Okla St | SR | LB | 4 | 1.0 | 4 | 0.25 |
| 26 | T'Vondre Sweat | Texas | JR | DL | 4 | 1.0 | 4 | 0.25 |
| 26 | Mike Rose | Iowa State | SR | LB | 4 | 1.0 | 3 | 0.25 |
| 26 | La'Kendrick Van Zandt | TCU | SR | S | 4 | 1.0 | 3 | 0.25 |
| 26 | Troy Te'o | Texas Tech | SR | DL | 4 | 1.0 | 1 | 0.25 |
| 26 | Ovie Oghoufo | Texas | JR | EDG | 4 | 1.0 | 1 | 0.25 |
| 45 | Jacob Morgenstern | Texas Tech | SR | LB | 5 | 1.0 | 15 | 0.20 |
| 45 | TJ Franklin | Baylor | JR | DL | 5 | 1.0 | 9 | 0.20 |
| 45 | Blake Peterson | Iowa State | SO | DE | 5 | 1.0 | 9 | 0.20 |
| 45 | Gabe Hall | Baylor | SO | DL | 5 | 1.0 | 8 | 0.20 |
| 45 | Tyree Wilson | Texas Tech | JR | DL | 5 | 1.0 | 8 | 0.20 |
| 45 | Jaylon Hutchings | Texas Tech | JR | DL | 5 | 1.0 | 8 | 0.20 |
Note: To qualify, player must have played in 75% of his team's games.