2021 Big 12 Conference Leaders Sacks - Games in October Only through 01/10/2022
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Felix Anudike-Uzomah | Kansas St | SO | DE | 4 | 6.0 | 32 | 1.50 |
| 2 | Dante Stills | WVU | SR | DL | 4 | 4.0 | 25 | 1.00 |
| 2 | Will McDonald IV | Iowa State | JR | DE | 4 | 4.0 | 24 | 1.00 |
| 2 | Collin Oliver | Okla St | FR | DE | 4 | 4.0 | 19 | 1.00 |
| 5 | Siaki Ika | Baylor | SO | DT | 4 | 3.5 | 23 | 0.88 |
| 6 | Terrel Bernard | Baylor | SR | LB | 3 | 2.0 | 14 | 0.67 |
| 7 | Ochaun Mathis | TCU | JR | DE | 5 | 3.0 | 21 | 0.60 |
| 7 | Tyree Wilson | Texas Tech | JR | DL | 5 | 3.0 | 20 | 0.60 |
| 7 | Isaiah Thomas | Oklahoma | SR | DL | 5 | 3.0 | 18 | 0.60 |
| 10 | Nik Bonitto | Oklahoma | JR | OLB | 5 | 2.5 | 19 | 0.50 |
| 10 | Jalen Pitre | Baylor | SR | S | 4 | 2.0 | 18 | 0.50 |
| 10 | TJ Franklin | Baylor | JR | DL | 4 | 2.0 | 18 | 0.50 |
| 10 | Eyioma Uwazurike | Iowa State | SR | DE | 4 | 2.0 | 17 | 0.50 |
| 10 | Kyron Johnson | Kansas | SR | DE | 4 | 2.0 | 13 | 0.50 |
| 15 | Dylan Horton | TCU | SR | DE | 5 | 2.0 | 21 | 0.40 |
| 16 | Akheem Mesidor | WVU | SO | DL | 4 | 1.5 | 7 | 0.38 |
| 17 | Ben Davis | Texas | SR | EDG | 3 | 1.0 | 1 | 0.33 |
| 18 | Anthony Cook | Texas | SR | DB | 4 | 1.0 | 16 | 0.25 |
| 18 | Devin Harper | Okla St | SR | LB | 4 | 1.0 | 12 | 0.25 |
| 18 | Dillon Doyle | Baylor | JR | LB | 4 | 1.0 | 11 | 0.25 |
| 18 | Caleb Sampson | Kansas | SR | DL | 4 | 1.0 | 11 | 0.25 |
| 18 | Josh Chandler-Semedo | WVU | SR | LB | 4 | 1.0 | 10 | 0.25 |
| 18 | DeMarvion Overshown | Texas | SR | LB | 4 | 1.0 | 9 | 0.25 |
| 18 | Jayden Jernigan | Okla St | SO | DT | 4 | 1.0 | 7 | 0.25 |
| 18 | Brendon Evers | Okla St | SR | DT | 4 | 1.0 | 7 | 0.25 |
| 18 | Keondre Coburn | Texas | JR | DL | 4 | 1.0 | 7 | 0.25 |
| 18 | Alfred Collins | Texas | SO | DL | 4 | 1.0 | 7 | 0.25 |
| 18 | Bryson Jackson | Baylor | SR | OLB | 4 | 1.0 | 6 | 0.25 |
| 18 | Nate Matlack | Kansas St | FR | DE | 4 | 1.0 | 6 | 0.25 |
| 18 | Timmy Horne | Kansas St | SR | DT | 4 | 1.0 | 5 | 0.25 |
| 18 | Garmon Randolph | Baylor | SO | OLB | 4 | 1.0 | 4 | 0.25 |
| 18 | Gavin Potter | Kansas | JR | LB | 4 | 1.0 | 2 | 0.25 |
| 33 | Jamoi Hodge | TCU | SO | LB | 5 | 1.0 | 8 | 0.20 |
| 33 | Jaylon Hutchings | Texas Tech | JR | DL | 5 | 1.0 | 8 | 0.20 |
| 33 | Khari Coleman | TCU | SO | DE | 5 | 1.0 | 7 | 0.20 |
| 33 | Colin Schooler | Texas Tech | SR | LB | 5 | 1.0 | 6 | 0.20 |
| 33 | Perrion Winfrey | Oklahoma | SR | DL | 5 | 1.0 | 4 | 0.20 |
| 38 | Zion DeBose | Kansas | SR | DE | 3 | 0.5 | 1 | 0.17 |
| 38 | Ronald McGee | Kansas | SR | DL | 3 | 0.5 | 1 | 0.17 |
| 40 | Jarrick Bernard-Converse | Okla St | SR | CB | 4 | 0.5 | 4 | 0.13 |
| 40 | Danny Stutsman | Oklahoma | FR | LB | 4 | 0.5 | 4 | 0.13 |
| 40 | Taijh Alston | WVU | JR | DL | 4 | 0.5 | 4 | 0.13 |
| 40 | Israel Antwine | Okla St | SR | DT | 4 | 0.5 | 3 | 0.13 |
| 40 | Cole Maxwell | Baylor | SR | DT | 4 | 0.5 | 1 | 0.13 |
Note: To qualify, player must have played in 75% of his team's games.