2021 Big 12 Conference Leaders Long All Purpose Plays - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Breece Hall | Iowa State | JR | RB | 5 | 7 | 4 | 3 | 2 | 2 | 1 | 0 |
| 1 | Malik Knowles | Kansas St | JR | WR | 6 | 6 | 3 | 2 | 2 | 0 | 0 | 0 |
| 3 | Kennedy Brooks | Oklahoma | JR | RB | 6 | 5 | 2 | 1 | 1 | 0 | 0 | 0 |
| 3 | Leddie Brown | WVU | SR | RB | 4 | 2 | 2 | 1 | 1 | 1 | 1 | 0 |
| 3 | Derius Davis | TCU | SR | WR | 4 | 3 | 3 | 1 | 1 | 1 | 1 | 1 |
| 3 | Ra'Mello Dotson | Kansas | FR | CB | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Loic Fouonji | Texas Tech | SO | WR | 5 | 2 | 2 | 1 | 1 | 0 | 0 | 0 |
| 3 | Kaylon Geiger Sr. | Texas Tech | SR | WR | 5 | 4 | 4 | 3 | 1 | 1 | 0 | 0 |
| 3 | Garrett Greene | WVU | FR | QB | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Will Howard | Kansas St | SO | QB | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Daniel Imatorbhebhe | Kansas St | SR | TE | 6 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Roschon Johnson | Texas | JR | RB | 4 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Kwamie Lassiter II | Kansas | SR | WR | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Kenny Logan Jr. | Kansas | JR | S | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Tarique Milton | Iowa State | SR | WR | 5 | 2 | 2 | 1 | 1 | 0 | 0 | 0 |
| 3 | Devin Neal | Kansas | FR | RB | 3 | 2 | 2 | 2 | 1 | 0 | 0 | 0 |
| 3 | Jaden Nixon | Okla St | FR | RB | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Bijan Robinson | Texas | SO | RB | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Keilan Robinson | Texas | JR | RB | 3 | 2 | 2 | 1 | 1 | 0 | 0 | 0 |
| 3 | R.J. Sneed | Baylor | SR | WR | 5 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | JD Spielman | TCU | SR | WR | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Jason Taylor II | Okla St | JR | S | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | SaRodorick Thompson | Texas Tech | JR | RB | 5 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Tyquan Thornton | Baylor | SR | WR | 5 | 4 | 4 | 1 | 1 | 1 | 0 | 0 |
| 3 | Deuce Vaughn | Kansas St | SO | RB | 6 | 7 | 5 | 2 | 1 | 1 | 1 | 0 |
| 3 | Marquis Waters | Texas Tech | SR | DB | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Trevon West | Oklahoma | SO | WR | 6 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Caleb Williams | Oklahoma | FR | QB | 4 | 3 | 3 | 1 | 1 | 0 | 0 | 0 |