2021 Big 12 Conference Leaders Long All Purpose Plays - Games vs. FBS Teams With Winning Record Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Xavier Worthy | Texas | FR | WR | 8 | 7 | 4 | 3 | 3 | 1 | 0 | 0 |
| 2 | Taye Barber | TCU | SR | WR | 7 | 3 | 3 | 3 | 2 | 1 | 0 | 0 |
| 2 | Derius Davis | TCU | SR | WR | 7 | 6 | 3 | 2 | 2 | 1 | 0 | 0 |
| 2 | Trestan Ebner | Baylor | SR | RB | 8 | 6 | 3 | 2 | 2 | 1 | 1 | 1 |
| 2 | Malik Knowles | Kansas St | JR | WR | 6 | 5 | 3 | 2 | 2 | 2 | 2 | 2 |
| 2 | Kendre Miller | TCU | SO | RB | 5 | 5 | 4 | 3 | 2 | 1 | 0 | 0 |
| 7 | Nik Bonitto | Oklahoma | JR | OLB | 5 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 7 | LD Brown | Okla St | SR | RB | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 7 | Breece Hall | Iowa State | JR | RB | 6 | 6 | 3 | 1 | 1 | 1 | 0 | 0 |
| 7 | Daniel Imatorbhebhe | Kansas St | SR | TE | 5 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 7 | Quentin Johnston | TCU | SO | WR | 5 | 4 | 2 | 2 | 1 | 1 | 0 | 0 |
| 7 | Travis Koontz | Texas Tech | SR | TE | 6 | 3 | 2 | 1 | 1 | 1 | 0 | 0 |
| 7 | Marvin Mims | Oklahoma | SO | WR | 6 | 4 | 4 | 2 | 1 | 0 | 0 | 0 |
| 7 | Brennan Presley | Okla St | SO | WR | 9 | 6 | 4 | 1 | 1 | 1 | 1 | 1 |
| 7 | Abram Smith | Baylor | SR | RB | 8 | 5 | 3 | 2 | 1 | 1 | 0 | 0 |
| 7 | Deuce Vaughn | Kansas St | SO | RB | 6 | 3 | 2 | 2 | 1 | 0 | 0 | 0 |
| 7 | Al Walcott | Baylor | JR | CB | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 7 | Jaylen Warren | Okla St | SR | RB | 9 | 2 | 2 | 2 | 1 | 1 | 0 | 0 |
| 7 | Caleb Williams | Oklahoma | FR | QB | 6 | 2 | 2 | 2 | 1 | 1 | 0 | 0 |
| 7 | Winston Wright Jr. | WVU | JR | WR | 8 | 3 | 2 | 1 | 1 | 1 | 1 | 1 |