2021 Big 12 Conference Leaders Passing - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brock Purdy | Iowa State | SR | QB | 5 | 173 | 115 | 66.5 | 1193 | 6.9 | 5 | 6 | 127.00 | 34.6 | 238.6 |
| 2 | Spencer Sanders | Okla St | JR | QB | 4 | 150 | 97 | 64.7 | 1024 | 6.8 | 6 | 9 | 123.22 | 37.5 | 256.0 |
| 3 | Casey Thompson | Texas | JR | QB | 5 | 112 | 67 | 59.8 | 945 | 8.4 | 9 | 3 | 151.86 | 22.4 | 189.0 |
| 4 | Jarret Doege | WVU | SR | QB | 3 | 82 | 55 | 67.1 | 506 | 6.2 | 1 | 3 | 115.62 | 27.3 | 168.7 |
| 5 | Caleb Williams | Oklahoma | FR | QB | 3 | 84 | 50 | 59.5 | 636 | 7.6 | 6 | 2 | 141.93 | 28.0 | 212.0 |
| 5 | Gerry Bohanon | Baylor | JR | QB | 4 | 94 | 50 | 53.2 | 561 | 6.0 | 3 | 3 | 107.47 | 23.5 | 140.3 |
| 7 | Skylar Thompson | Kansas St | SR | QB | 2 | 70 | 44 | 62.9 | 478 | 6.8 | 3 | 0 | 134.36 | 35.0 | 239.0 |
| 8 | Donovan Smith | Texas Tech | FR | QB | 3 | 75 | 42 | 56.0 | 544 | 7.3 | 3 | 1 | 127.46 | 25.0 | 181.3 |
| 9 | Chandler Morris | TCU | FR | QB | 2 | 61 | 40 | 65.6 | 586 | 9.6 | 2 | 0 | 157.09 | 30.5 | 293.0 |
| 10 | Jason Bean | Kansas | JR | QB | 3 | 50 | 28 | 56.0 | 313 | 6.3 | 2 | 2 | 113.78 | 16.7 | 104.3 |
| 11 | Blake Shapen | Baylor | FR | QB | 1 | 28 | 23 | 82.1 | 180 | 6.4 | 3 | 0 | 171.50 | 28.0 | 180.0 |
| 12 | Hudson Card | Texas | FR | QB | 3 | 36 | 22 | 61.1 | 285 | 7.9 | 2 | 0 | 145.94 | 12.0 | 95.0 |
| 13 | Max Duggan | TCU | JR | QB | 1 | 30 | 20 | 66.7 | 346 | 11.5 | 4 | 0 | 207.55 | 30.0 | 346.0 |
| 14 | Tyler Shough | Texas Tech | JR | QB | 1 | 24 | 17 | 70.8 | 231 | 9.6 | 1 | 0 | 165.43 | 24.0 | 231.0 |
| 15 | Hunter Dekkers | Iowa State | FR | QB | 2 | 25 | 16 | 64.0 | 143 | 5.7 | 2 | 1 | 130.45 | 12.5 | 71.5 |
| 16 | Jaren Lewis | Kansas St | SO | QB | 2 | 20 | 10 | 50.0 | 148 | 7.4 | 1 | 2 | 108.66 | 10.0 | 74.0 |
| 17 | Garrett Greene | WVU | FR | QB | 3 | 12 | 8 | 66.7 | 61 | 5.1 | 0 | 0 | 109.37 | 4.0 | 20.3 |
| 18 | Henry Colombi | Texas Tech | SR | QB | 1 | 12 | 7 | 58.3 | 77 | 6.4 | 1 | 1 | 123.06 | 12.0 | 77.0 |
| 19 | Miles Kendrick | Kansas | SR | QB | 2 | 8 | 6 | 75.0 | 34 | 4.3 | 0 | 1 | 85.70 | 4.0 | 17.0 |
| 20 | Will Howard | Kansas St | SO | QB | 1 | 12 | 4 | 33.3 | 50 | 4.2 | 0 | 0 | 68.33 | 12.0 | 50.0 |
| 20 | Spencer Rattler | Oklahoma | SO | QB | 1 | 6 | 4 | 66.7 | 36 | 6.0 | 0 | 0 | 117.07 | 6.0 | 36.0 |
| 22 | Sam Jackson | TCU | FR | QB | 1 | 1 | 1 | 100.0 | 77 | 77.0 | 0 | 0 | 746.80 | 1.0 | 77.0 |
| 22 | Taye Barber | TCU | SR | WR | 3 | 1 | 1 | 100.0 | 7 | 7.0 | 0 | 0 | 158.80 | 0.3 | 2.3 |
| 22 | Brennan Presley | Okla St | SO | WR | 4 | 1 | 1 | 100.0 | 6 | 6.0 | 0 | 0 | 150.40 | 0.3 | 1.5 |
| 22 | Behren Morton | Texas Tech | FR | QB | 1 | 3 | 1 | 33.3 | 0 | 0.0 | 0 | 0 | 33.33 | 3.0 | 0.0 |