2021 Big 12 Conference Leaders Passing - Games in October Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Caleb Williams | Oklahoma | FR | QB | 5 | 99 | 73 | 73.7 | 1105 | 11.2 | 14 | 1 | 212.15 | 19.8 | 221.0 |
| 2 | Brock Purdy | Iowa State | SR | QB | 4 | 107 | 82 | 76.6 | 945 | 8.8 | 8 | 0 | 175.50 | 26.8 | 236.3 |
| 3 | Skylar Thompson | Kansas St | SR | QB | 4 | 115 | 81 | 70.4 | 1074 | 9.3 | 7 | 2 | 165.50 | 28.8 | 268.5 |
| 4 | Max Duggan | TCU | JR | QB | 5 | 107 | 73 | 68.2 | 949 | 8.9 | 7 | 2 | 160.57 | 21.4 | 189.8 |
| 5 | Jarret Doege | WVU | SR | QB | 4 | 138 | 96 | 69.6 | 1182 | 8.6 | 5 | 3 | 149.13 | 34.5 | 295.5 |
| 6 | Casey Thompson | Texas | JR | QB | 4 | 121 | 70 | 57.9 | 989 | 8.2 | 9 | 4 | 144.45 | 30.3 | 247.3 |
| 7 | Spencer Sanders | Okla St | JR | QB | 4 | 98 | 59 | 60.2 | 742 | 7.6 | 7 | 4 | 139.21 | 24.5 | 185.5 |
| 8 | Gerry Bohanon | Baylor | JR | QB | 4 | 115 | 66 | 57.4 | 930 | 8.1 | 5 | 3 | 134.45 | 28.8 | 232.5 |
| 9 | Henry Colombi | Texas Tech | SR | QB | 5 | 124 | 77 | 62.1 | 959 | 7.7 | 2 | 4 | 125.94 | 24.8 | 191.8 |
| 10 | Jason Bean | Kansas | JR | QB | 4 | 74 | 41 | 55.4 | 456 | 6.2 | 1 | 4 | 100.82 | 18.5 | 114.0 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 15.0 pass attempts per game played.