2021 Big 12 Conference Leaders Passing - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Caleb Williams | Oklahoma | FR | QB | 9 | 201 | 131 | 65.2 | 1828 | 9.1 | 21 | 4 | 172.07 | 22.3 | 203.1 |
| 2 | Skylar Thompson | Kansas St | SR | QB | 9 | 229 | 159 | 69.4 | 2017 | 8.8 | 12 | 3 | 158.09 | 25.4 | 224.1 |
| 3 | Max Duggan | TCU | JR | QB | 8 | 180 | 115 | 63.9 | 1565 | 8.7 | 12 | 5 | 153.36 | 22.5 | 195.6 |
| 4 | Casey Thompson | Texas | JR | QB | 10 | 238 | 146 | 61.3 | 1908 | 8.0 | 21 | 8 | 151.09 | 23.8 | 190.8 |
| 5 | Brock Purdy | Iowa State | SR | QB | 11 | 357 | 250 | 70.0 | 2701 | 7.6 | 16 | 8 | 143.89 | 32.5 | 245.5 |
| 6 | Gerry Bohanon | Baylor | JR | QB | 9 | 201 | 123 | 61.2 | 1568 | 7.8 | 14 | 6 | 143.73 | 22.3 | 174.2 |
| 7 | Jarret Doege | WVU | SR | QB | 12 | 395 | 258 | 65.3 | 2789 | 7.1 | 16 | 12 | 131.92 | 32.9 | 232.4 |
| 8 | Spencer Sanders | Okla St | JR | QB | 10 | 302 | 188 | 62.3 | 2213 | 7.3 | 14 | 11 | 131.83 | 30.2 | 221.3 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 15.0 pass attempts per game played.