2021 Big 12 Conference Leaders Yards From Scrimmage - Games in October Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Recv Yards | TD | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Xavier Worthy | Texas | FR | WR | 4 | 7 | 411 | 3 | 20 | 418 | 20.9 | 104.5 |
| 2 | Tyquan Thornton | Baylor | SR | WR | 4 | 0 | 377 | 2 | 21 | 377 | 18.0 | 94.3 |
| 3 | Tay Martin | Okla St | SR | WR | 4 | 0 | 322 | 2 | 21 | 322 | 15.3 | 80.5 |
| 4 | Winston Wright Jr. | WVU | JR | WR | 4 | 1 | 351 | 1 | 26 | 352 | 13.5 | 88.0 |
| 5 | Erik Ezukanma | Texas Tech | JR | WR | 4 | 82 | 225 | 3 | 24 | 307 | 12.8 | 76.8 |
| 6 | Xavier Hutchinson | Iowa State | SR | WR | 4 | 8 | 305 | 3 | 29 | 313 | 10.8 | 78.3 |
| 7 | Caleb Williams | Oklahoma | FR | QB | 5 | 220 | 0 | 3 | 26 | 220 | 8.5 | 44.0 |
| 8 | Kendre Miller | TCU | SO | RB | 5 | 414 | 104 | 5 | 62 | 518 | 8.4 | 103.6 |
| 9 | Abram Smith | Baylor | SR | RB | 4 | 517 | 15 | 6 | 72 | 532 | 7.4 | 133.0 |
| 10 | Eric Gray | Oklahoma | JR | RB | 5 | 80 | 121 | 1 | 29 | 201 | 6.9 | 40.2 |
| 11 | Breece Hall | Iowa State | JR | RB | 4 | 557 | 102 | 6 | 104 | 659 | 6.3 | 164.8 |
| 12 | Deuce Vaughn | Kansas St | SO | RB | 4 | 311 | 249 | 6 | 90 | 560 | 6.2 | 140.0 |
| 12 | SaRodorick Thompson | Texas Tech | JR | RB | 5 | 281 | 107 | 7 | 63 | 388 | 6.2 | 77.6 |
| 14 | Kennedy Brooks | Oklahoma | JR | RB | 5 | 575 | 15 | 6 | 96 | 590 | 6.1 | 118.0 |
| 15 | Bijan Robinson | Texas | SO | RB | 4 | 531 | 66 | 7 | 100 | 597 | 6.0 | 149.3 |
| 16 | Dominic Richardson | Okla St | SO | RB | 4 | 119 | 24 | 1 | 25 | 143 | 5.7 | 35.8 |
| 17 | Trestan Ebner | Baylor | SR | RB | 4 | 214 | 7 | 0 | 42 | 221 | 5.3 | 55.3 |
| 18 | Xavier White | Texas Tech | JR | RB | 5 | 132 | 58 | 2 | 38 | 190 | 5.0 | 38.0 |
| 19 | Jaylen Warren | Okla St | SR | RB | 4 | 463 | 31 | 2 | 102 | 494 | 4.8 | 123.5 |
| 20 | Joe Ervin | Kansas St | SO | RB | 3 | 90 | 0 | 0 | 19 | 90 | 4.7 | 30.0 |
| 21 | Leddie Brown | WVU | SR | RB | 4 | 321 | 67 | 6 | 87 | 388 | 4.5 | 97.0 |
| 21 | Spencer Sanders | Okla St | JR | QB | 4 | 178 | 0 | 2 | 40 | 178 | 4.5 | 44.5 |
| 21 | Emari Demercado | TCU | SR | RB | 5 | 111 | 10 | 1 | 27 | 121 | 4.5 | 24.2 |
| 24 | Devin Neal | Kansas | FR | RB | 4 | 262 | 5 | 2 | 64 | 267 | 4.2 | 66.8 |
| 25 | Amauri Pesek-Hickson | Kansas | FR | RB | 3 | 79 | 19 | 0 | 24 | 98 | 4.1 | 32.7 |
| 26 | Brock Purdy | Iowa State | SR | QB | 4 | 102 | 0 | 1 | 26 | 102 | 3.9 | 25.5 |
| 27 | Tony Mathis Jr. | WVU | SO | RB | 3 | 62 | 0 | 0 | 17 | 62 | 3.6 | 20.7 |
| 28 | Jason Bean | Kansas | JR | QB | 4 | 116 | 0 | 0 | 33 | 116 | 3.5 | 29.0 |
| 29 | Max Duggan | TCU | JR | QB | 5 | 140 | 0 | 0 | 46 | 140 | 3.0 | 28.0 |
| 30 | Torry Locklin | Kansas | SO | WR | 4 | 51 | 1 | 1 | 20 | 52 | 2.6 | 13.0 |
| 31 | Gerry Bohanon | Baylor | JR | QB | 4 | 56 | 0 | 3 | 23 | 56 | 2.4 | 14.0 |
| 32 | Casey Thompson | Texas | JR | QB | 4 | 38 | 0 | 0 | 27 | 38 | 1.4 | 9.5 |
| 32 | Henry Colombi | Texas Tech | SR | QB | 5 | 41 | 0 | 1 | 30 | 41 | 1.4 | 8.2 |
| 34 | Skylar Thompson | Kansas St | SR | QB | 4 | -8 | 0 | 2 | 20 | -8 | -0.4 | -2.0 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 5.0 plays per game played.