2021 Big 12 Conference Leaders Yards From Scrimmage - Games in December/January Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Recv Yards | TD | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Myles Price | Texas Tech | SO | WR | 1 | 15 | 72 | 0 | 5 | 87 | 17.4 | 87.0 |
| 2 | Phillip Brooks | Kansas St | JR | WR | 1 | 0 | 69 | 0 | 5 | 69 | 13.8 | 69.0 |
| 3 | Brennan Presley | Okla St | SO | WR | 2 | 9 | 157 | 0 | 14 | 166 | 11.9 | 83.0 |
| 4 | Tay Martin | Okla St | SR | WR | 2 | 0 | 192 | 3 | 19 | 192 | 10.1 | 96.0 |
| 5 | Kennedy Brooks | Oklahoma | JR | RB | 1 | 142 | 24 | 3 | 17 | 166 | 9.8 | 166.0 |
| 6 | Eric Gray | Oklahoma | JR | RB | 1 | 82 | 25 | 1 | 13 | 107 | 8.2 | 107.0 |
| 7 | John Paul Richardson | Okla St | FR | WR | 2 | -1 | 75 | 0 | 10 | 74 | 7.4 | 37.0 |
| 8 | Justin Johnson Jr. | WVU | FR | RB | 1 | 35 | 0 | 0 | 5 | 35 | 7.0 | 35.0 |
| 9 | Tahj Brooks | Texas Tech | SO | RB | 1 | 107 | 0 | 1 | 16 | 107 | 6.7 | 107.0 |
| 10 | Deuce Vaughn | Kansas St | SO | RB | 1 | 146 | -3 | 4 | 23 | 143 | 6.2 | 143.0 |
| 11 | Donovan Smith | Texas Tech | FR | QB | 1 | 30 | 0 | 1 | 5 | 30 | 6.0 | 30.0 |
| 12 | Xavier White | Texas Tech | JR | RB | 1 | 10 | 19 | 0 | 5 | 29 | 5.8 | 29.0 |
| 13 | SaRodorick Thompson | Texas Tech | JR | RB | 1 | 80 | 0 | 1 | 14 | 80 | 5.7 | 80.0 |
| 13 | Trestan Ebner | Baylor | SR | RB | 2 | 53 | 27 | 0 | 14 | 80 | 5.7 | 40.0 |
| 15 | Abram Smith | Baylor | SR | RB | 2 | 235 | 6 | 0 | 43 | 241 | 5.6 | 120.5 |
| 16 | Marcus Major | Oklahoma | SO | RB | 1 | 54 | 0 | 0 | 10 | 54 | 5.4 | 54.0 |
| 17 | Spencer Sanders | Okla St | JR | QB | 2 | 154 | 6 | 0 | 31 | 160 | 5.2 | 80.0 |
| 18 | Caleb Williams | Oklahoma | FR | QB | 1 | 34 | 0 | 0 | 7 | 34 | 4.9 | 34.0 |
| 19 | Jaylen Warren | Okla St | SR | RB | 2 | 82 | 34 | 0 | 25 | 116 | 4.6 | 58.0 |
| 20 | Tony Mathis Jr. | WVU | SO | RB | 1 | 56 | 24 | 0 | 18 | 80 | 4.4 | 80.0 |
| 21 | Kaylon Geiger Sr. | Texas Tech | SR | WR | 1 | 18 | 9 | 0 | 7 | 27 | 3.9 | 27.0 |
| 22 | Jirehl Brock | Iowa State | SO | RB | 1 | 42 | 21 | 0 | 17 | 63 | 3.7 | 63.0 |
| 23 | Brock Purdy | Iowa State | SR | QB | 1 | 14 | 0 | 0 | 5 | 14 | 2.8 | 14.0 |
| 24 | Skylar Thompson | Kansas St | SR | QB | 1 | 10 | 0 | 0 | 5 | 10 | 2.0 | 10.0 |
| 25 | Dominic Richardson | Okla St | SO | RB | 2 | 5 | 8 | 1 | 10 | 13 | 1.3 | 6.5 |
| 26 | Jarret Doege | WVU | SR | QB | 1 | -22 | 0 | 1 | 8 | -22 | -2.8 | -22.0 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 5.0 plays per game played.