2021 Big 12 Conference Leaders Rushing Defense - Games at Home Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma | 7 | 230 | 655 | 2.85 | 6 | 32.86 | 93.57 |
| 2 | Iowa State | 6 | 215 | 630 | 2.93 | 2 | 35.83 | 105.00 |
| 3 | Oklahoma State | 7 | 239 | 815 | 3.41 | 5 | 34.14 | 116.43 |
| 4 | Baylor | 7 | 228 | 842 | 3.69 | 10 | 32.57 | 120.29 |
| 5 | Kansas State | 7 | 245 | 873 | 3.56 | 9 | 35.00 | 124.71 |
| 6 | West Virginia | 6 | 197 | 766 | 3.89 | 8 | 32.83 | 127.67 |
| 7 | Texas Tech | 6 | 208 | 828 | 3.98 | 11 | 34.67 | 138.00 |
| 8 | Texas | 6 | 221 | 1014 | 4.59 | 10 | 36.83 | 169.00 |
| 9 | TCU | 7 | 269 | 1348 | 5.01 | 12 | 38.43 | 192.57 |
| 10 | Kansas | 6 | 242 | 1432 | 5.92 | 18 | 40.33 | 238.67 |