2021 Big 12 Conference Leaders Rushing Defense - Games in November Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 4 | 135 | 364 | 2.70 | 1 | 33.75 | 91.00 |
| 2 | Baylor | 4 | 113 | 405 | 3.58 | 5 | 28.25 | 101.25 |
| 3 | Kansas State | 4 | 148 | 548 | 3.70 | 2 | 37.00 | 137.00 |
| 4 | West Virginia | 4 | 127 | 554 | 4.36 | 6 | 31.75 | 138.50 |
| 5 | Texas Tech | 3 | 123 | 457 | 3.72 | 4 | 41.00 | 152.33 |
| 6 | Iowa State | 4 | 142 | 647 | 4.56 | 4 | 35.50 | 161.75 |
| 7 | Oklahoma | 3 | 118 | 488 | 4.14 | 6 | 39.33 | 162.67 |
| 8 | Texas | 4 | 155 | 779 | 5.03 | 9 | 38.75 | 194.75 |
| 9 | Kansas | 4 | 161 | 993 | 6.17 | 10 | 40.25 | 248.25 |
| 10 | TCU | 4 | 152 | 1029 | 6.77 | 15 | 38.00 | 257.25 |