2021 Big 12 Conference Leaders Scoring Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Baylor | 5 | 10 | 5 | 10 | 0 | 0 | 85 | 17.0 |
| 2 | Iowa State | 5 | 16 | 5 | 16 | 0 | 0 | 127 | 25.4 |
| 3 | Oklahoma State | 4 | 14 | 1 | 14 | 0 | 1 | 103 | 25.8 |
| 4 | West Virginia | 3 | 10 | 5 | 10 | 0 | 0 | 85 | 28.3 |
| 5 | Kansas State | 3 | 10 | 6 | 10 | 0 | 0 | 88 | 29.3 |
| 6 | Texas Tech | 4 | 15 | 6 | 15 | 0 | 0 | 123 | 30.8 |
| 7 | Oklahoma | 3 | 12 | 4 | 10 | 1 | 0 | 96 | 32.0 |
| 8 | Texas | 5 | 19 | 15 | 15 | 1 | 0 | 176 | 35.2 |
| 9 | Kansas | 3 | 18 | 3 | 18 | 0 | 0 | 135 | 45.0 |
| 10 | TCU | 3 | 20 | 1 | 20 | 0 | 0 | 143 | 47.7 |