2021 Big 12 Conference Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | West Virginia | 3 | 331 | 792 | 190 | 1123 | 5.91 | 374.3 |
| 2 | Kansas State | 3 | 442 | 818 | 220 | 1260 | 5.73 | 420.0 |
| 3 | Oklahoma | 3 | 628 | 637 | 207 | 1265 | 6.11 | 421.7 |
| 4 | Iowa State | 5 | 629 | 767 | 294 | 1396 | 4.75 | 279.2 |
| 5 | Kansas | 3 | 812 | 690 | 202 | 1502 | 7.44 | 500.7 |
| 6 | Oklahoma State | 4 | 400 | 1114 | 290 | 1514 | 5.22 | 378.5 |
| 7 | TCU | 3 | 856 | 744 | 201 | 1600 | 7.96 | 533.3 |
| 8 | Texas Tech | 4 | 517 | 1136 | 299 | 1653 | 5.53 | 413.3 |
| 9 | Baylor | 5 | 572 | 1149 | 365 | 1721 | 4.72 | 344.2 |
| 10 | Texas | 5 | 1199 | 1117 | 372 | 2316 | 6.23 | 463.2 |