2021 Big 12 Conference Leaders Scoring Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Iowa State | 8 | 18 | 5 | 17 | 0 | 0 | 140 | 17.5 |
| 2 | Texas | 7 | 25 | 7 | 24 | 1 | 0 | 197 | 28.1 |
| 2 | Kansas | 9 | 50 | 7 | 50 | 0 | 0 | 371 | 41.2 |
| 4 | Oklahoma | 10 | 31 | 8 | 27 | 1 | 0 | 239 | 23.9 |
| 4 | Texas Tech | 9 | 35 | 8 | 33 | 0 | 1 | 269 | 29.9 |
| 6 | TCU | 9 | 35 | 12 | 28 | 1 | 0 | 276 | 30.7 |
| 7 | Oklahoma State | 10 | 16 | 13 | 15 | 0 | 0 | 150 | 15.0 |
| 7 | Kansas State | 10 | 21 | 13 | 18 | 0 | 1 | 185 | 18.5 |
| 7 | Baylor | 9 | 19 | 13 | 18 | 0 | 0 | 171 | 19.0 |
| 10 | West Virginia | 10 | 26 | 14 | 23 | 2 | 0 | 225 | 22.5 |