2021 Big 12 Conference Leaders Total Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 10 | 827 | 1829 | 620 | 2656 | 4.28 | 265.6 |
| 2 | Iowa State | 8 | 961 | 1668 | 504 | 2629 | 5.22 | 328.6 |
| 3 | Kansas State | 10 | 1244 | 1980 | 615 | 3224 | 5.24 | 322.4 |
| 4 | Baylor | 9 | 1080 | 2043 | 576 | 3123 | 5.42 | 347.0 |
| 5 | West Virginia | 10 | 1473 | 1958 | 631 | 3431 | 5.44 | 343.1 |
| 6 | Oklahoma | 10 | 1049 | 2766 | 680 | 3815 | 5.61 | 381.5 |
| 7 | Texas | 7 | 1220 | 1571 | 475 | 2791 | 5.88 | 398.7 |
| 8 | Texas Tech | 9 | 1269 | 2351 | 600 | 3620 | 6.03 | 402.2 |
| 9 | TCU | 9 | 1808 | 2133 | 567 | 3941 | 6.95 | 437.9 |
| 10 | Kansas | 9 | 2186 | 2147 | 607 | 4333 | 7.14 | 481.4 |