2021 Big 12 Conference Leaders Rushing Defense - Games in August/September Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | TCU | 3 | 108 | 544 | 5.04 | 4 | 36.00 | 181.33 |
| 2 | Oklahoma | 4 | 126 | 317 | 2.52 | 4 | 31.50 | 79.25 |
| 3 | Kansas State | 4 | 128 | 301 | 2.35 | 4 | 32.00 | 75.25 |
| 4 | Iowa State | 4 | 129 | 275 | 2.13 | 2 | 32.25 | 68.75 |
| 5 | Oklahoma State | 4 | 136 | 348 | 2.56 | 3 | 34.00 | 87.00 |
| 6 | Baylor | 4 | 140 | 565 | 4.04 | 4 | 35.00 | 141.25 |
| 7 | Texas | 4 | 141 | 681 | 4.83 | 7 | 35.25 | 170.25 |
| 8 | West Virginia | 4 | 145 | 362 | 2.50 | 1 | 36.25 | 90.50 |
| 9 | Texas Tech | 4 | 146 | 499 | 3.42 | 6 | 36.50 | 124.75 |
| 10 | Kansas | 4 | 178 | 966 | 5.43 | 16 | 44.50 | 241.50 |