2021 Big 12 Conference Leaders Rushing Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | West Virginia | 3 | 92 | 331 | 3.60 | 3 | 30.67 | 110.33 |
| 2 | Oklahoma | 3 | 116 | 628 | 5.41 | 6 | 38.67 | 209.33 |
| 3 | Kansas State | 3 | 123 | 442 | 3.59 | 4 | 41.00 | 147.33 |
| 4 | Kansas | 3 | 126 | 812 | 6.44 | 10 | 42.00 | 270.67 |
| 5 | Oklahoma State | 4 | 127 | 400 | 3.15 | 2 | 31.75 | 100.00 |
| 6 | TCU | 3 | 133 | 856 | 6.44 | 12 | 44.33 | 285.33 |
| 7 | Texas Tech | 4 | 153 | 517 | 3.38 | 3 | 38.25 | 129.25 |
| 8 | Iowa State | 5 | 178 | 629 | 3.53 | 5 | 35.60 | 125.80 |
| 9 | Baylor | 5 | 206 | 572 | 2.78 | 7 | 41.20 | 114.40 |
| 10 | Texas | 5 | 209 | 1199 | 5.74 | 13 | 41.80 | 239.80 |