2021 Big 12 Conference Leaders Rushing Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 10 | 321 | 899 | 2.80 | 6 | 32.10 | 89.90 |
| 2 | Iowa State | 11 | 392 | 1505 | 3.84 | 11 | 35.64 | 136.82 |
| 2 | Kansas State | 11 | 395 | 1561 | 3.95 | 11 | 35.91 | 141.91 |
| 4 | Baylor | 11 | 406 | 1345 | 3.31 | 12 | 36.91 | 122.27 |
| 5 | Oklahoma | 11 | 383 | 1522 | 3.97 | 13 | 34.82 | 138.36 |
| 6 | West Virginia | 12 | 422 | 1769 | 4.19 | 15 | 35.17 | 147.42 |
| 7 | Texas Tech | 10 | 351 | 1623 | 4.62 | 16 | 35.10 | 162.30 |
| 8 | Texas | 10 | 409 | 2199 | 5.38 | 25 | 40.90 | 219.90 |
| 9 | TCU | 10 | 379 | 2253 | 5.94 | 32 | 37.90 | 225.30 |
| 10 | Kansas | 10 | 414 | 2618 | 6.32 | 34 | 41.40 | 261.80 |