2021 Big 12 Conference Leaders Rushing Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Iowa State | 1 | 31 | 40 | 1.29 | 0 | 31.00 | 40.00 |
| 2 | Kansas State | 1 | 23 | 25 | 1.09 | 1 | 23.00 | 25.00 |
| 2 | Texas | 2 | 61 | 220 | 3.61 | 1 | 30.50 | 110.00 |
| 4 | Texas Tech | 2 | 64 | 132 | 2.06 | 2 | 32.00 | 66.00 |
| 4 | Oklahoma | 1 | 32 | 100 | 3.13 | 2 | 32.00 | 100.00 |
| 4 | TCU | 1 | 52 | 350 | 6.73 | 2 | 52.00 | 350.00 |
| 7 | Baylor | 2 | 51 | 146 | 2.86 | 3 | 25.50 | 73.00 |
| 7 | Oklahoma State | 3 | 95 | 226 | 2.38 | 3 | 31.67 | 75.33 |
| 9 | Kansas | 1 | 40 | 215 | 5.38 | 4 | 40.00 | 215.00 |