2021 Big 12 Conference Leaders Scoring Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Baylor | 11 | 23 | 15 | 22 | 0 | 0 | 205 | 18.6 |
| 1 | Iowa State | 11 | 33 | 8 | 32 | 0 | 0 | 254 | 23.1 |
| 1 | West Virginia | 12 | 36 | 19 | 33 | 2 | 0 | 310 | 25.8 |
| 1 | Oklahoma | 11 | 38 | 12 | 34 | 1 | 0 | 300 | 27.3 |
| 1 | Texas | 10 | 42 | 20 | 39 | 2 | 0 | 355 | 35.5 |
| 1 | TCU | 10 | 49 | 12 | 44 | 0 | 0 | 374 | 37.4 |
| 1 | Kansas | 10 | 59 | 10 | 59 | 0 | 0 | 443 | 44.3 |
| 8 | Oklahoma State | 10 | 19 | 8 | 19 | 0 | 1 | 159 | 15.9 |
| 8 | Kansas State | 11 | 26 | 17 | 24 | 0 | 1 | 233 | 21.2 |
| 8 | Texas Tech | 10 | 42 | 11 | 41 | 0 | 1 | 328 | 32.8 |