2021 Big 12 Conference Leaders Total Offense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 4 | 670 | 933 | 302 | 1603 | 5.31 | 400.8 |
| 2 | Oklahoma | 4 | 909 | 1117 | 290 | 2026 | 6.99 | 506.5 |
| 3 | Baylor | 4 | 1245 | 714 | 271 | 1959 | 7.23 | 489.8 |
| 4 | West Virginia | 4 | 492 | 954 | 266 | 1446 | 5.44 | 361.5 |
| 5 | Iowa State | 4 | 473 | 964 | 257 | 1437 | 5.59 | 359.3 |
| 6 | Texas Tech | 4 | 772 | 1064 | 248 | 1836 | 7.40 | 459.0 |
| 7 | Kansas State | 4 | 860 | 704 | 238 | 1564 | 6.57 | 391.0 |
| 8 | Kansas | 3 | 461 | 724 | 207 | 1185 | 5.72 | 395.0 |
| 9 | TCU | 3 | 619 | 763 | 201 | 1382 | 6.88 | 460.7 |
| 10 | Texas | 3 | 735 | 576 | 194 | 1311 | 6.76 | 437.0 |