2021 Atlantic Coast Conference Leaders Total Offense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brennan Armstrong | Virginia | JR | QB | 3 | 100 | 1231 | 178 | 1331 | 7.48 | 443.7 |
| 2 | Malik Cunningham | Louisville | JR | QB | 5 | 370 | 1038 | 214 | 1408 | 6.58 | 281.6 |
| 3 | Sam Howell | N Carolina | JR | QB | 4 | 332 | 1000 | 189 | 1332 | 7.05 | 333.0 |
| 4 | Sam Hartman | Wk Forest | SO | QB | 3 | 6 | 815 | 174 | 821 | 4.72 | 273.7 |
| 5 | Tyler Van Dyke | Miami (Fl) | FR | QB | 3 | 6 | 751 | 92 | 757 | 8.23 | 252.3 |
| 6 | Devin Leary | NC State | SO | QB | 2 | -24 | 646 | 114 | 622 | 5.46 | 311.0 |
| 7 | Garrett Shrader | Syracuse | SO | QB | 4 | 252 | 631 | 177 | 883 | 4.99 | 220.8 |
| 8 | DJ Uiagalelei | Clemson | SO | QB | 4 | 121 | 625 | 146 | 746 | 5.11 | 186.5 |
| 9 | D'Eriq King | Miami (Fl) | SR | QB | 2 | 17 | 567 | 110 | 584 | 5.31 | 292.0 |
| 10 | Kenny Pickett | Pittsburgh | SR | QB | 2 | 35 | 555 | 85 | 590 | 6.94 | 295.0 |
| 11 | Dennis Grosel | BC | SR | QB | 2 | -31 | 505 | 91 | 474 | 5.21 | 237.0 |
| 12 | Jordan Travis | FSU | SO | QB | 3 | 21 | 413 | 86 | 434 | 5.05 | 144.7 |
| 13 | McKenzie Milton | FSU | SR | QB | 3 | 8 | 400 | 83 | 408 | 4.92 | 136.0 |
| 14 | Jordan Yates | Ga Tech | FR | QB | 4 | 13 | 372 | 110 | 385 | 3.50 | 96.3 |
| 15 | Jeff Sims | Ga Tech | FR | QB | 1 | 38 | 359 | 43 | 397 | 9.23 | 397.0 |
| 16 | Braxton Burmeister | Va Tech | JR | QB | 2 | 61 | 318 | 81 | 379 | 4.68 | 189.5 |
| 17 | Gunnar Holmberg | Duke | SR | QB | 2 | -30 | 284 | 57 | 254 | 4.46 | 127.0 |
| 18 | Jay Woolfolk | Virginia | FR | QB | 2 | 21 | 231 | 56 | 252 | 4.50 | 126.0 |
| 19 | Davis Beville | Pittsburgh | SO | QB | 1 | -30 | 149 | 25 | 119 | 4.76 | 119.0 |
| 20 | Riley Leonard | Duke | FR | QB | 2 | 70 | 108 | 36 | 178 | 4.94 | 89.0 |
| 21 | Evan Conley | Louisville | SO | QB | 3 | 26 | 63 | 15 | 89 | 5.93 | 29.7 |
| 22 | Michael Kern | Wk Forest | FR | QB | 1 | 0 | 58 | 1 | 58 | 58.00 | 58.0 |
| 23 | Taisun Phommachanh | Clemson | SO | QB | 2 | 15 | 23 | 9 | 38 | 4.22 | 19.0 |
| 24 | Nick Patti | Pittsburgh | JR | QB | 2 | 27 | 21 | 8 | 48 | 6.00 | 24.0 |
| 25 | Jared Wayne | Pittsburgh | JR | WR | 3 | 0 | 20 | 1 | 20 | 20.00 | 6.7 |
| 26 | Phil Jurkovec | BC | JR | QB | 1 | 66 | 19 | 22 | 85 | 3.86 | 85.0 |
| 27 | Braden Smith | Louisville | SO | WR | 1 | 0 | 9 | 1 | 9 | 9.00 | 9.0 |
| 28 | Luca Diamont | Duke | FR | QB | 1 | 38 | 4 | 3 | 42 | 14.00 | 42.0 |
| 29 | Connor Blumrick | Va Tech | JR | QB | 1 | 29 | 3 | 9 | 32 | 3.56 | 32.0 |
| 29 | JaCobian Morgan | Syracuse | FR | QB | 1 | 0 | 3 | 1 | 3 | 3.00 | 3.0 |
| 31 | Will Shipley | Clemson | FR | RB | 4 | 207 | 2 | 45 | 209 | 4.64 | 52.3 |