2021 Atlantic Coast Conference Leaders Interceptions - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | A.J. Woods | Pittsburgh | JR | DB | 3 | 1 | 73 | 0 | 0.33 |
| 2 | SirVocea Dennis | Pittsburgh | JR | LB | 3 | 1 | 50 | 1 | 0.33 |
| 3 | Jammie Robinson | FSU | SO | DB | 4 | 1 | 47 | 0 | 0.25 |
| 4 | Tyrique Stevenson | Miami (Fl) | SO | CB | 4 | 1 | 39 | 0 | 0.25 |
| 5 | Joey Blount | Virginia | SR | FS | 4 | 1 | 33 | 0 | 0.25 |
| 6 | Qwynnterrio Cole | Louisville | SR | DB | 5 | 1 | 29 | 0 | 0.20 |
| 7 | Jermaine Waller | Va Tech | JR | DB | 2 | 1 | 26 | 1 | 0.50 |
| 8 | Cam'Ron Kelly | N Carolina | JR | DB | 4 | 2 | 21 | 0 | 0.50 |
| 9 | Erick Hallett II | Pittsburgh | JR | DB | 3 | 2 | 19 | 1 | 0.67 |
| 10 | Damarri Mathis | Pittsburgh | SR | DB | 2 | 1 | 15 | 0 | 0.50 |
| 11 | Nasir Peoples | Va Tech | SO | DB | 2 | 1 | 14 | 0 | 0.50 |
| 12 | Shyheim Battle | NC State | FR | CB | 2 | 1 | 5 | 0 | 0.50 |
| 12 | Travis Jay | FSU | FR | DB | 3 | 1 | 5 | 0 | 0.33 |
| 12 | Darian Chestnut | Syracuse | FR | DB | 4 | 1 | 5 | 0 | 0.25 |
| 15 | Jason Simmons | Syracuse | SO | DB | 4 | 1 | 4 | 0 | 0.25 |
| 16 | Baylon Spector | Clemson | SR | LB | 4 | 1 | 3 | 0 | 0.25 |