2021 Atlantic Coast Conference Leaders Interceptions - Games in August/September Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Jaylin Alderman | Louisville | FR | LB | 4 | 1 | 66 | 1 | 0.25 |
| 1 | Fentrell Cypress II | Virginia | SO | DB | 5 | 1 | 66 | 0 | 0.20 |
| 3 | Ja'Sir Taylor | Wk Forest | SR | DB | 4 | 1 | 47 | 0 | 0.25 |
| 4 | Jermaine Waller | Va Tech | JR | DB | 4 | 3 | 41 | 0 | 0.75 |
| 5 | R.J. Mickens | Clemson | SO | S | 4 | 1 | 37 | 0 | 0.25 |
| 6 | Damarri Mathis | Pittsburgh | SR | DB | 4 | 1 | 35 | 1 | 0.25 |
| 7 | Caelen Carson | Wk Forest | FR | DB | 4 | 2 | 30 | 0 | 0.50 |
| 8 | Shaka Heyward | Duke | JR | LB | 4 | 1 | 26 | 0 | 0.25 |
| 9 | Brandon Hill | Pittsburgh | SO | DB | 4 | 1 | 25 | 0 | 0.25 |
| 10 | Jeremiah Lewis | Duke | JR | CB | 3 | 1 | 23 | 0 | 0.33 |
| 10 | Darian Chestnut | Syracuse | FR | DB | 4 | 1 | 23 | 0 | 0.25 |
| 12 | Jahmin Muse | BC | SR | DB | 4 | 1 | 22 | 1 | 0.25 |
| 13 | Power Echols | N Carolina | FR | LB | 4 | 1 | 17 | 0 | 0.25 |
| 14 | Cyrus Fagan | NC State | SR | SAF | 2 | 1 | 16 | 0 | 0.50 |
| 15 | Nasir Greer | Wk Forest | JR | DB | 2 | 1 | 14 | 0 | 0.50 |
| 16 | Corey Flagg, Jr. | Miami (Fl) | FR | LB | 5 | 1 | 9 | 0 | 0.20 |
| 17 | Tyler Baker-Williams | NC State | JR | NIC | 4 | 1 | 7 | 0 | 0.25 |
| 18 | Tanner Ingle | NC State | JR | SAF | 4 | 1 | 6 | 0 | 0.25 |
| 19 | Travis Jay | FSU | FR | DB | 4 | 1 | 5 | 0 | 0.25 |
| 20 | Leonard Johnson | Duke | SR | CB | 4 | 1 | 4 | 0 | 0.25 |
| 21 | Baylon Spector | Clemson | SR | LB | 3 | 1 | 3 | 0 | 0.33 |
| 22 | Kei'Trel Clark | Louisville | SO | DB | 4 | 3 | 2 | 0 | 0.75 |
| 22 | Lummie Young IV | Duke | SR | S | 4 | 1 | 2 | 0 | 0.25 |