2021 Atlantic Coast Conference Leaders Total Defense - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 6 | 573 | 1175 | 397 | 1748 | 4.40 | 291.3 |
| 2 | Louisville | 5 | 686 | 1197 | 366 | 1883 | 5.14 | 376.6 |
| 3 | North Carolina | 5 | 780 | 1184 | 320 | 1964 | 6.14 | 392.8 |
| 4 | Syracuse | 6 | 925 | 1064 | 392 | 1989 | 5.07 | 331.5 |
| 5 | Florida State | 6 | 1020 | 1112 | 425 | 2132 | 5.02 | 355.3 |
| 6 | Miami (Florida) | 6 | 993 | 1195 | 437 | 2188 | 5.01 | 364.7 |
| 7 | Pittsburgh | 7 | 487 | 1901 | 470 | 2388 | 5.08 | 341.1 |
| 8 | North Carolina State | 7 | 1051 | 1367 | 476 | 2418 | 5.08 | 345.4 |
| 9 | Georgia Tech | 5 | 932 | 1558 | 374 | 2490 | 6.66 | 498.0 |
| 10 | Boston College | 8 | 1400 | 1304 | 494 | 2704 | 5.47 | 338.0 |
| 11 | Virginia Tech | 7 | 1324 | 1498 | 472 | 2822 | 5.98 | 403.1 |
| 12 | Virginia | 6 | 1441 | 1457 | 424 | 2898 | 6.83 | 483.0 |
| 13 | Wake Forest | 9 | 1662 | 1784 | 612 | 3446 | 5.63 | 382.9 |
| 14 | Duke | 8 | 1636 | 2468 | 547 | 4104 | 7.50 | 513.0 |