2021 Atlantic Coast Conference Leaders Total Defense - Games at Home Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 6 | 324 | 1312 | 396 | 1636 | 4.13 | 272.7 |
| 2 | Boston College | 6 | 776 | 1198 | 379 | 1974 | 5.21 | 329.0 |
| 3 | Syracuse | 7 | 613 | 1409 | 472 | 2022 | 4.28 | 288.9 |
| 4 | Wake Forest | 6 | 820 | 1420 | 407 | 2240 | 5.50 | 373.3 |
| 5 | North Carolina State | 7 | 1123 | 1155 | 438 | 2278 | 5.20 | 325.4 |
| 6 | Louisville | 7 | 1083 | 1396 | 466 | 2479 | 5.32 | 354.1 |
| 7 | Miami (Florida) | 7 | 1003 | 1549 | 492 | 2552 | 5.19 | 364.6 |
| 8 | Florida State | 7 | 784 | 1781 | 491 | 2565 | 5.22 | 366.4 |
| 9 | Pittsburgh | 7 | 652 | 1944 | 475 | 2596 | 5.47 | 370.9 |
| 10 | Georgia Tech | 6 | 1140 | 1465 | 387 | 2605 | 6.73 | 434.2 |
| 11 | Virginia Tech | 7 | 1270 | 1375 | 504 | 2645 | 5.25 | 377.9 |
| 12 | Virginia | 7 | 1362 | 1413 | 482 | 2775 | 5.76 | 396.4 |
| 13 | North Carolina | 7 | 1147 | 1727 | 495 | 2874 | 5.81 | 410.6 |
| 14 | Duke | 7 | 1458 | 2045 | 512 | 3503 | 6.84 | 500.4 |