2021 Atlantic Coast Conference Leaders Scoring Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 9 | 11 | 8 | 10 | 0 | 1 | 102 | 11.3 |
| 2 | Louisville | 8 | 20 | 9 | 18 | 0 | 0 | 165 | 20.6 |
| 3 | North Carolina State | 10 | 20 | 10 | 20 | 0 | 0 | 170 | 17.0 |
| 4 | Boston College | 9 | 22 | 6 | 21 | 0 | 1 | 173 | 19.2 |
| 5 | Florida State | 8 | 24 | 6 | 20 | 1 | 0 | 184 | 23.0 |
| 6 | Syracuse | 8 | 21 | 13 | 20 | 1 | 0 | 187 | 23.4 |
| 7 | Miami (Florida) | 8 | 23 | 10 | 19 | 3 | 1 | 195 | 24.4 |
| 8 | Virginia | 8 | 25 | 9 | 22 | 1 | 1 | 203 | 25.4 |
| 9 | Georgia Tech | 8 | 28 | 13 | 25 | 2 | 0 | 236 | 29.5 |
| 10 | North Carolina | 9 | 31 | 11 | 27 | 4 | 0 | 254 | 28.2 |
| 11 | Pittsburgh | 11 | 34 | 8 | 32 | 0 | 1 | 262 | 23.8 |
| 12 | Virginia Tech | 11 | 34 | 11 | 32 | 0 | 0 | 269 | 24.5 |
| 12 | Wake Forest | 11 | 34 | 11 | 32 | 0 | 0 | 269 | 24.5 |
| 14 | Duke | 10 | 48 | 15 | 45 | 0 | 0 | 378 | 37.8 |